FDPS
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Official Full Name
cross-linked fibrin degradation products -
Overview
During blood coagulation, fibrinogen is converted to fibrin by the activation of thrombin. The resulting fibrin monomers polymerize to form a soluble gel of non-cross-linked fibrin. This fibrin gel is then converted to cross-linked fibrin by thrombin activated Factor XIII to form an insoluble fibrin clot. Production of plasmin, the major clot-lysing enzyme, is triggered when a fibrin clot is formed. Fibrinogen and fibrin are both cleaved by the fibrinolytic enzyme plasmin to yield degradation products, but only degradation products from crosslinked fibrin contain D-Dimer. Therefore, cross-linked fibrin degradation products (XL-FDP) are a specific marker of fibrinolysis. -
Synonyms
FDPs;Fibrin Degradation Products;Geranyltranstransferase;(2E;6E)-farnesyl diphosphate synthase;dimethylallyltranstransferase;Farnesyl diphosphate synthase;Farnesyl diphosphate synthetase;Farnesyl pyrophosphate synthase;Farnesyl pyrophosphate synthetase;Fdps;FPP synthase;FPP synthetase;FPPS;FPS
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&GST
- Non
- His&Fc&Avi
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FDPS-12834H | Recombinant Human FDPS, GST-tagged | E.coli | Human | GST | 68-419a.a. | |
| Fdps-1001M | Recombinant Mouse Fdps protein, His-tagged | E.coli | Mouse | His | Met1-Lys353 |
|
| FDPS-1150H | Recombinant Human FDPS protein, His & GST-tagged | E.coli | Human | His&GST | Met1~Lys419 |
|
| Fdps-1151R | Recombinant Rat Fdps protein, His & GST-tagged | E.coli | Rat | His&GST | Met1~Lys353 |
|
| FDPS-2309R | Recombinant Rat FDPS Protein | Mammalian Cell | Rat | His |
|
|
| FDPS-28480TH | Recombinant Human FDPS | Wheat Germ | Human | Non | 100 amino acids |
|
| FDPS-3109Z | Recombinant Zebrafish FDPS | Mammalian Cell | Zebrafish | His |
|
|
| FDPS-517H | Recombinant Human FDPS protein(Met1-Lys353), His-tagged | E.coli | Human | His | 1-353 a.a. |
|
| FDPS-5804M | Recombinant Mouse FDPS Protein | Mammalian Cell | Mouse | His |
|
|
| FDPS-615HCL | Recombinant Human FDPS cell lysate | Human | Non |
|
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| FDPS-1966R | Recombinant Rat FDPS Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
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| FDPS-1966R-B | Recombinant Rat FDPS Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
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| FDPS-2895H | Recombinant Human FDPS protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 1-419aa |
|
| FDPS-3202M | Recombinant Mouse FDPS Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| FDPS-3202M-B | Recombinant Mouse FDPS Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
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| FDPS-4058H | Recombinant Human FDPS Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| FDPS-4775HF | Recombinant Full Length Human FDPS Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 419 amino acids |
|
Involved Pathway
FDPS involved in several pathways and played different roles in them. We selected most pathways FDPS participated on our site, such as Terpenoid backbone biosynthesis,Metabolic pathways,Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with FDPS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Influenza A | IFNA16,HLA-DQB1,EP300,NLRX1,MAPK3,ICAM1,HSPA1B,TNFSF10,HSPA2,EIF2AK1 |
| HTLV-I infection | WNT3,RB1,CDC23,SMAD4,CRTC2,SFPI1,Il2,SLC25A6,PIK3CA,KAT2A |
| Metabolic pathways | POLR2A,HIBADH,INPP5KA,COX7B2,ACSL4A,MAN2A2,COQ3,PNPLA3,ALG6,PIGQ |
| Terpenoid backbone biosynthesis | HMGCS2,IDI2,ZMPSTE24,ACAT2,GGPS1,HMGCR,PDSS2,ACAT1,PCYOX1,MVK |
Protein Function
FDPS has several biochemical functions, for example, dimethylallyltranstransferase activity,geranyltranstransferase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FDPS itself. We selected most functions FDPS had, and list some proteins which have the same functions with FDPS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dimethylallyltranstransferase activity | GGPS1 |
| metal ion binding | ZFYVE16,ZFP36L1,FAM20B,CRYAB,ATP2B3B,ZXDC,ZBTB9,GFI1B,BCL11AB,ZFP503 |
| geranyltranstransferase activity | GGPS1 |
| poly(A) RNA binding | NOVA1,TRA2A,SCAF4,HNRNPA1,PDIA4,RSRC2,SSBP1,DDX46,FNDC3A,MYO5A |
Interacting Protein
FDPS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FDPS here. Most of them are supplied by our site. Hope this information will be useful for your research of FDPS.
EIF4ENIF1;ATXN1;q81kq8_bacan;cydC;TSG101
Resources
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References
- Zhang, LW; McCabe, T; et al. An Anti-PCSK9 Antibody Reduces LDL-Cholesterol On Top Of A Statin And Suppresses Hepatocyte SREBP-Regulated Genes. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 8:310-327(2012).
- Wada, H; Sakuragawa, N; et al. Are fibrin-related markers useful for the diagnosis of thrombosis?. SEMINARS IN THROMBOSIS AND HEMOSTASIS 34:33-38(2008).
