FCRL2
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Official Full Name
Fc receptor-like 2 -
Overview
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. -
Synonyms
FCRL2;Fc receptor-like 2;SH2 domain containing phosphatase anchor protein 1 , SPAP1;Fc receptor-like protein 2;CD307b;FCRH2;IRTA4;fcR-like protein 2;IFGP family protein 4;fc receptor homolog 2;immunoglobulin superfamily Fc receptor, gp42;SH2 do
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- Mammalian cells
- HEK293
- Mammalian Cell
- Wheat Germ
- HEK293T
- His
- Non
- Fc
- hIgG4
- GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
FCRL2 involved in several pathways and played different roles in them. We selected most pathways FCRL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FCRL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
FCRL2 has several biochemical functions, for example, SH3/SH2 adaptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCRL2 itself. We selected most functions FCRL2 had, and list some proteins which have the same functions with FCRL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3/SH2 adaptor activity | SOCS2,SH2D2A,SKAP2,ARHGAP1,GRB2,STAP1,GRB7,CHN1,SKAP1,GRB14 |
| protein binding | KCNIP1,COMMD6,SH2B2,FAM64A,PARP16,POU5F1,RAB24,BNIP2,MLF1,HNRNPA1 |
Interacting Protein
FCRL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCRL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FCRL2.
NCK2
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References
- Shabani, M; Bayat, AA; et al. Ligation of human Fc receptor like-2 by monoclonal antibodies down-regulates B-cell receptor-mediated signalling. IMMUNOLOGY 143:341-353(2014).
- Disanto, G; Sandve, GK; et al. DNase hypersensitive sites and association with multiple sclerosis. HUMAN MOLECULAR GENETICS 23:942-948(2014).
