FBXW2

  • Official Full Name

    F-box and WD repeat domain containing 2

  • Overview

    F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.

  • Synonyms

    FBXW2;F-box and WD repeat domain containing 2;F box and WD 40 domain protein 2;F-box/WD repeat-containing protein 2;FBW2;Fwd2;Md6;F-box and WD-40 domain protein 2;F-box and WD-40 domain-containing protein 2;MGC117371

Recombinant Proteins

  • Human
  • Chicken
  • Rat
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
FBXW2-12810H Recombinant Human FBXW2, GST-tagged E.coli Human GST N-term-314a.a.
FBXW2-1767C Recombinant Chicken FBXW2 Mammalian Cell Chicken His
FBXW2-2302R Recombinant Rat FBXW2 Protein Mammalian Cell Rat His
FBXW2-2668Z Recombinant Zebrafish FBXW2 Mammalian Cell Zebrafish His
FBXW2-3970H Recombinant Human FBXW2 Protein, GST-tagged Wheat Germ Human GST
FBXW2-6285HCL Recombinant Human FBXW2 293 Cell Lysate HEK293 Human Non
FBXW2-1959R Recombinant Rat FBXW2 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
FBXW2-1959R-B Recombinant Rat FBXW2 Protein Pre-coupled Magnetic Beads HEK293 Rat
FBXW2-4702HF Recombinant Full Length Human FBXW2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 454 amino acids

    Involved Pathway

    FBXW2 involved in several pathways and played different roles in them. We selected most pathways FBXW2 participated on our site, such as Association of TriC/CCT with target proteins during biosynthesis,Chaperonin-mediated protein folding,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXW2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism of proteins SEC23IP,TUBA1B,TOMM70A,CPA3,ACE,TIMM22,CGB5,IGFBP6B,SLC25A12,FBXW9
    Chaperonin-mediated protein folding PFDN6,PFDN4,TUBA3D,TCP1,PFDN2,TUBA1B,CCT5,TUBB4A,VBP1,PFDN5
    Protein folding FBXW5,TBCD,FBXW4,ARL2,CCT7,CCT6A,TBCB,SERPINA7,PFDN2,NOP56
    Wnt Signaling Pathway and Pluripotency PPM1J,ZBTB33,FOXD3,LRRK2
    Association of TriC/CCT with target proteins during biosynthesis CCT4,NOP56,CCT5,CCT6A,CCT7,CCT2,KIFC3,FBXL5,FBXW9,TCP1
    Wnt signaling pathway FBXW11A,WNT5B,FZD5,CTBP2A,PRKACA,RAC3B,BAMBIB,DVL1B,FZD8,SIAH1A

    Protein Function

    FBXW2 has several biochemical functions, for example, protein binding,ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXW2 itself. We selected most functions FBXW2 had, and list some proteins which have the same functions with FBXW2. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin-protein transferase activity TRIM68,TRIM71,RNF38,TRIM2,CBL,TRIM9,BIRC5,RNF213,FBXO4,RNF135
    protein binding EIF3F,LGI1,HIRIP3,SAFB,Arid4b,USP17L2,NR1H2,CNKSR1,MEIOB,NUTF2

    Interacting Protein

    FBXW2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXW2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXW2.

    SKP1;CUL1;CDC37;HSP90AB1;SKP1;NUDC;b4dyc6_human;HSP90AA1;STIP1;q53fc7_human;HSP90AB1;NUDCD2;PPP5C

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