FBXO3
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Official Full Name
F-box protein 3 -
Overview
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3 end. -
Synonyms
FBXO3;F-box protein 3;F box only protein 3;F-box only protein 3;FBA;FBX3;F box protein 3;F box protein FBX3;F-box protein FBX3
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- Yeast
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- Flag
- His&GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
FBXO3 involved in several pathways and played different roles in them. We selected most pathways FBXO3 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome degradation | ASB9,TRIM63,ASB13,STUB1,SPSB1,TRIM50,DTX3L,RNF25,TPP2,ASB4 |
| Class I MHC mediated antigen processing & | ASB4,UBR1,CYBA,KLHL21,RNF144B,ASB11,RNF14,ASB13,WSB1,RNF220 |
| Immune System | DCTN6,ASB18,ASB10,KLC3,CTSLL,CD300E,ASB13,BTR16,RNF182,IRF9 |
| Adaptive Immune System | UBE2V1,CD160,UBR2,CYBA,MICA,KIF3B,RNF220,RASGRP1,CLEC2D,GRAP2A |
| Antigen processing: Ubiquitination & | ASB6,MKRN1,DZIP3,ASB3,ASB2,TRIM63,WSB1,ASB17,TRIM9,TRIM50 |
| presentation | ASB2,FCGR1B,ASB11,RNF14,SEC23A,BLMH,ASB10,LRRC41,ASB17,UFL1 |
Protein Function
FBXO3 has several biochemical functions, for example, protein binding,ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO3 itself. We selected most functions FBXO3 had, and list some proteins which have the same functions with FBXO3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SERBP1,GZMM,ZNF32,NUDT12,HOMEZ,ENC1,SULT2B1,CATSPERG2,MED9,NOL9 |
| ubiquitin-protein transferase activity | MDM2,TTC3,PEX12,MYCBP2,LMO7,IRAK1,UBE2D4,MARCH4,RAG1,RFWD3 |
Interacting Protein
FBXO3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO3.
SKP1;tat;HSP90AB1;TNIP3;q99ib8-pro_0000045599;NSS
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References
- Kainulainen, M; Habjan, M; et al. Virulence Factor NSs of Rift Valley Fever Virus Recruits the F-Box Protein FBXO3 To Degrade Subunit p62 of General Transcription Factor TFIIH. JOURNAL OF VIROLOGY 88:3464-3473(2014).
- Mallampalli, RK; Coon, TA; et al. Targeting F Box Protein Fbxo3 To Control Cytokine-Driven Inflammation. JOURNAL OF IMMUNOLOGY 191:5247-5255(2013).
