FBXL5
-
Official Full Name
F-box and leucine-rich repeat protein 5 -
Overview
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010] -
Synonyms
FBXL5;F-box and leucine-rich repeat protein 5;FBL4;FBL5;FLR1;F-box/LRR-repeat protein 5;F-box protein FBL5;p45SKP2-like protein;F-box protein FBL4/FBL5
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FBXL5-12780H | Recombinant Human FBXL5, His-tagged | E.coli | Human | His | 1-250a.a. | |
| FBXL5-3907H | Recombinant Human FBXL5 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| FBXL5-479H | Recombinant Human FBXL5 Protein, GST-His-tagged | E.coli | Human | His&GST |
|
|
| FBXL5-5725M | Recombinant Mouse FBXL5 Protein | Mammalian Cell | Mouse | His |
|
|
| FBXL5-8468Z | Recombinant Zebrafish FBXL5 | Mammalian Cell | Zebrafish | His |
|
|
| FBXL5-6310HCL | Recombinant Human FBXL5 293 Cell Lysate | HEK293 | Human | Non |
|
|
| FBXL5-3149M | Recombinant Mouse FBXL5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| FBXL5-3149M-B | Recombinant Mouse FBXL5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
||
| FBXL5-5002HF | Recombinant Full Length Human FBXL5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 691 amino acids |
|
Involved Pathway
FBXL5 involved in several pathways and played different roles in them. We selected most pathways FBXL5 participated on our site, such as Association of TriC/CCT with target proteins during biosynthesis,Chaperonin-mediated protein folding,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chaperonin-mediated protein folding | CCT6A,FKBP9,TUBA3D,PFDN4,CCT2,VBP1,NOP56,PFDN6,PFDN1,FBXW9 |
| Metabolism of proteins | MBOAT4,C19orf10,GALNT5,TOMM22,WDR85,VBP1,GALNT6,PROZ,MUC5AC,NSMCE2 |
| Protein folding | TBCB,PFDN5,KIFC3,ARL2,NOP56,SERPINA7,FBXW9,FBXW4,PFDN4,FKBP9 |
| Association of TriC/CCT with target proteins during biosynthesis | CCT2,KIFC3,NOP56,FBXW2,CCT5,CCT8,TCP1,CCT7,FBXW4,FKBP9 |
Protein Function
FBXL5 has several biochemical functions, for example, iron ion binding,protein binding,contributes_to ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXL5 itself. We selected most functions FBXL5 had, and list some proteins which have the same functions with FBXL5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ubiquitin protein ligase activity | FBXL3,FBXL22,FBXL2,FBXL17,FBXL20,MED11,FBXL14A,FBXL3B,CUL4A,FBXL12 |
| ubiquitin-protein transferase activity | NHLRC1,FANCL,MDM2,BARD1,BIRC5A,ZNRF3,UBE2B,RNF6,BIRC5B,UHRF2 |
| protein binding | MYBBP1A,DCP2,CXCR4,MOCS3,PTPN13,ABCG2,FOS,SYTL4,H3F3C,KIAA1143 |
| iron ion binding | NOS2A,CYP2AA6,SC4MOL,AOX1,PLOD1A,HBE1,ALOX12B,CYP2AA2,CYP2C54,HBB-Y |
Interacting Protein
FBXL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXL5.
SKP1;ORC4;MYB;PLK1;CSNK2B;EP300;rpoB
Resources
Related Services
Related Products
References
- Feng, JJ; Wang, JH; et al. High-throughput deep sequencing reveals that microRNAs play important roles in salt tolerance of euhalophyte Salicornia europaea. BMC PLANT BIOLOGY 15:-(2015).
- Kawakami, E; Tokunaga, A; et al. The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators. MECHANISMS OF DEVELOPMENT 135:31-42(2015).
