FARSB
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Official Full Name
phenylalanyl-tRNA synthetase, beta subunit -
Overview
This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer -
Synonyms
FARSB;phenylalanyl-tRNA synthetase, beta subunit;FARSLB, phenylalanyl tRNA synthetase like, beta subunit;phenylalanine--tRNA ligase beta subunit;FRSB;PheHB;phenylalanine tRNA ligase 1;beta;cytoplasmic;phenylalanine-tRNA ligase beta chain;phenyl;PheRS;FARSLB;HSPC173;phenylalanyl-tRNA synthetase beta chain;OTTHUMP00000164205;phenylalanine--tRNA ligase beta chain;phenylalanyl-tRNA synthetase beta-subunit;phenylalanine tRNA ligase 1, beta, cytoplasmic;phenylalanyl-tRNA synthetase-like, beta subunit;phenylalanine-tRNA synthetase-like, beta subunit
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FARSB-12750H | Recombinant Human FARSB, His-tagged | E.coli | Human | His | 240-589a.a. |
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| FARSB-1681C | Recombinant Chicken FARSB | Mammalian Cell | Chicken | His |
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| FARSB-1844Z | Recombinant Zebrafish FARSB | Mammalian Cell | Zebrafish | His |
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| FARSB-3848H | Recombinant Human FARSB Protein, GST-tagged | Wheat Germ | Human | GST |
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| FARSB-5684M | Recombinant Mouse FARSB Protein | Mammalian Cell | Mouse | His |
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| FARSB-6325HCL | Recombinant Human FARSB 293 Cell Lysate | HEK293 | Human | Non |
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| FARSB-1461H | Recombinant Human FARSB Protein, His-tagged | E.coli | Human | His | Met1-Val289 |
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| Farsb-1462M | Recombinant Mouse Farsb Protein, His-tagged | E.coli | Mouse | His | Met1-Val222 |
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| Farsb-2956M | Recombinant Mouse Farsb Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| FARSB-3120M | Recombinant Mouse FARSB Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FARSB-3120M-B | Recombinant Mouse FARSB Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FARSB-3392H | Recombinant Human FARSB Protein (Met1-Leu589), N-His tagged | E.coli | Human | His | Met1-Leu589 |
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| FARSB-4086H | Recombinant Human FARSB Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| FARSB-4771HF | Recombinant Full Length Human FARSB Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 589 amino acids |
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Involved Pathway
FARSB involved in several pathways and played different roles in them. We selected most pathways FARSB participated on our site, such as Aminoacyl-tRNA biosynthesis,Cytosolic tRNA aminoacylation,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with FARSB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| tRNA Aminoacylation | WARS2,MADD,AIMP2,KARS,AARS,EEF1E1,FARS2,EARS2,DARS,AIMP1 |
| Aminoacyl-tRNA biosynthesis | TARSL2,IARS,PARS2,EARS2,TARS,GARS,MADD,WARS,FARSA,SARS2 |
| Gene Expression | C2orf29,COX18,SKI,MED6,RPP30,ZNF222,ZNF212,ZNF691,NR2F6B,SUZ12B |
| Cytosolic tRNA aminoacylation | AIMP1,EEF1E1,AARS,KARS,DARS,MADD,AIMP2 |
Protein Function
FARSB has several biochemical functions, for example, ATP binding,RNA binding,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FARSB itself. We selected most functions FARSB had, and list some proteins which have the same functions with FARSB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MINK1,P2RX7,TRPM6,TOR1B,UBE2H,GUK1,NAIP6,GRK7A,PRKG1,CSNK1G2 |
| magnesium ion binding | STK11,CDC42BPA,GEM,FARS2,MAP3K5,ENO4,S100P,TESC,IMPA1,FAN1 |
| phenylalanine-tRNA ligase activity | FARSA,FDXACB1,FARS2 |
| RNA binding | HNRNPH2,LRPPRC,UBR5,RBM20,IGHMBP2,QKI2,RPL9,SRSF12,ALYREF,TUT1 |
Interacting Protein
FARSB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FARSB here. Most of them are supplied by our site. Hope this information will be useful for your research of FARSB.
VCAM1;ACTB;DDA1;FN1;EIF2AK2;HDGF;SLX4
Resources
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References
- Carr, JF; Danziger, ME; et al. Engineering the Genome of Thermus thermophilus Using a Counterselectable Marker. JOURNAL OF BACTERIOLOGY 197:1135-1144(2015).
- Mermershtain, I; Finarov, I; et al. Idiosyncrasy and identity in the prokaryotic phe-system: Crystal structure of E-coli phenylalanyl-tRNA synthetase complexed with phenylalanine and AMP. PROTEIN SCIENCE 20:160-167(2011).
