FANCI
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Official Full Name
Fanconi anemia, complementation group I -
Overview
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms. -
Synonyms
FANCI;Fanconi anemia, complementation group I;KIAA1794;Fanconi anemia group I protein;FLJ10719;FLJ14658;Protein FANCI
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FANCI-12740H | Recombinant Human FANCI, GST-tagged | E.coli | Human | GST | 1-252a.a. | |
| FANCI-0404H | Recombinant Human FANCI protein, His-tagged | E.coli | Human | His | 1-252 aa | |
| FANCI-3824C | Recombinant Chicken FANCI | Mammalian Cell | Chicken | His |
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| FANCI-4675Z | Recombinant Zebrafish FANCI | Mammalian Cell | Zebrafish | His |
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| FANCI-5673M | Recombinant Mouse FANCI Protein | Mammalian Cell | Mouse | His |
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| FANCI-627HCL | Recombinant Human FANCI cell lysate | Human | Non |
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| FANCI-3111M | Recombinant Mouse FANCI Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FANCI-3111M-B | Recombinant Mouse FANCI Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FANCI-4220H | Recombinant Human FANCI Protein, GST-tagged | Wheat Germ | Human | GST |
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| FANCI-4844HF | Recombinant Full Length Human FANCI Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 73 amino acids |
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Involved Pathway
FANCI involved in several pathways and played different roles in them. We selected most pathways FANCI participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FANCI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi Anemia Pathway | C19orf40,ERCC4,TOP3B,POLK,DCLRE1A,RPA3,EME1,REV3L,FANCM,UBE2T |
Protein Function
FANCI has several biochemical functions, for example, DNA binding,DNA polymerase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FANCI itself. We selected most functions FANCI had, and list some proteins which have the same functions with FANCI. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA polymerase binding | HMGB1,SMARCA4,PCNA,RAD51,CDK2AP1,LONP1,FANCD2,ACD |
| DNA binding | KDM5B,SSH3,POLR2E,NR0B2,POLL,DRAP1,GTF2F2B,RAD54B,PBX3B,CLOCK |
| protein binding | KRT25,TUT1,VPS26A,PSMA3,NSMCE4A,SPSB2,ATP6V1D,MOBKL2B,NPRL2,PKN3 |
Interacting Protein
FANCI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FANCI here. Most of them are supplied by our site. Hope this information will be useful for your research of FANCI.
FANCD2;ILK;FSCN1;PRKAB2;PTP4A3;MYC;TNFRSF1A;TNFRSF1B;CLN3;TSC22D1;CAMKK2;C20orf24;BRF2;NEK6;USP36;GSTK1
Resources
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References
- Raghunandan, M; Chaudhury, I; et al. FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex. CELL CYCLE 14:342-353(2015).
- Gibbs-Seymour, I; Oka, Y; et al. Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage. MOLECULAR CELL 57:150-164(2015).
