Extl1
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Official Full Name
EXTL1 exostoses (multiple)-like 1 [ Homo sapiens ] -
Overview
This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin. -
Synonyms
exostoses (multiple)-like 1;3515;Ensembl:ENSG00000158008;MGC70794;exostosin-like 1;exostosin-L;multiple exostosis-like protein;alpha-N-acetylglucosaminyltransferase II;glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase;glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N- acetylglucosaminyltransferase;glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase;2.4.1.224;EXTL
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EXTL1-12605H | Recombinant Human EXTL1, His-tagged | E.coli | Human | His | 328-676a.a. | |
| EXTL1-3587H | Recombinant Human EXTL1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| EXTL1-6495HCL | Recombinant Human EXTL1 293 Cell Lysate | HEK293 | Human | Non |
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| EXTL1-2684H | Recombinant Human EXTL1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Extl1-2896M | Recombinant Mouse Extl1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
Extl1 involved in several pathways and played different roles in them. We selected most pathways Extl1 participated on our site, such as Glycosaminoglycan biosynthesis - heparan sulfate / heparin,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with Extl1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | TSTA3,NME3,B3GALT1,LAP3,DEGS1,CYP2A4,ADC,GRHPR,MT-ND1,AGPS |
| Glycosaminoglycan biosynthesis - heparan sulfate / heparin | HS3ST2,HS6ST2,MAPK1IP1L,HS6ST3,HS6ST1,HS3ST3A1,NDST4,GLCEA,NDST3,GLCE |
Protein Function
Extl1 has several biochemical functions, for example, glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Extl1 itself. We selected most functions Extl1 had, and list some proteins which have the same functions with Extl1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity | EXT2,EXT1,EXT1B,EXT1A,EXT1C |
Interacting Protein
Extl1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Extl1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Extl1.
GRB2;SDR16C5
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References
- Blei, T; Soukup, ST; et al. Dose-dependent effects of isoflavone exposure during early lifetime on the rat mammary gland: Studies on estrogen sensitivity, isoflavone metabolism, and DNA methylation. MOLECULAR NUTRITION & FOOD RESEARCH 59:270-283(2015).
- Duchez, S; Pascal, V; et al. Glycotranscriptome study reveals an enzymatic switch modulating glycosaminoglycan synthesis during B-cell development and activation. EUROPEAN JOURNAL OF IMMUNOLOGY 41:3632-3644(2011).
