EYA2
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Official Full Name
eyes absent homolog 2 -
Overview
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally;modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator.;Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants;have not yet been determined. -
Synonyms
EYA2;eyes absent homolog 2 (Drosophila);eyes absent (Drosophila) homolog 2;eyes absent homolog 2;EAB1;MGC10614
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&SUMO
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EYA2-3101H | Recombinant Human EYA2 protein, His-tagged | E.coli | Human | His | 241-583 aa | |
| EYA2-1281Z | Recombinant Zebrafish EYA2 | Mammalian Cell | Zebrafish | His |
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| EYA2-18H | Recombinant Human EYA2 protein, His-tagged | E.coli | Human | His | 244-514 a.a. |
|
| EYA2-3592H | Recombinant Human EYA2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| EYA2-5397M | Recombinant Mouse EYA2 Protein | Mammalian Cell | Mouse | His |
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| EYA2-6477C | Recombinant Chicken EYA2 | Mammalian Cell | Chicken | His |
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| EYA2-6491HCL | Recombinant Human EYA2 293 Cell Lysate | HEK293 | Human | Non |
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| EYA2-2876H | Recombinant Human EYA2 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 1-514aa |
|
| EYA2-2910M | Recombinant Mouse EYA2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| EYA2-2910M-B | Recombinant Mouse EYA2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| EYA2-4457HF | Recombinant Full Length Human EYA2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 538 amino acids |
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Involved Pathway
EYA2 involved in several pathways and played different roles in them. We selected most pathways EYA2 participated on our site, such as DNA Double Strand Break Response,DNA Double-Strand Break Repair,DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with EYA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Double Strand Break Response | CHEK2,RAD50,KDM4A,FAM175A,UIMC1,SMARCA5,KDM4B,BRE,THRSP,BRCC3 |
| DNA Double-Strand Break Repair | BABAM1,PARP2,KDM4B,HTATIP,RNF168,RAD17,BAZ1B,WRN,BRE,PPP4CA |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | EYA3,KDM4A,KDM4B,EYA4,BAZ1B |
| DNA Repair | RAD51AP1,ELL,PARP2,EYA4,COPS4,PAXIP1,TOPBP1,TIMELESS,ACTR5,USP10 |
Protein Function
EYA2 has several biochemical functions, for example, magnesium ion binding,protein binding,protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EYA2 itself. We selected most functions EYA2 had, and list some proteins which have the same functions with EYA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CC2D1B,TEF,AHSA2,SEC61B,PHF23,ANXA7,CCT5,THBS2,THEMIS2,LPL |
| protein tyrosine phosphatase activity | PTPN11,KIAA1274,EVLA,PTPN3,PTPRU,DUSP7,DUSP22B,DUSP10,PTP4A2A,PTPN2A |
| magnesium ion binding | SIK3,PKMA,IDH3G,DCTPP1,ATP8A1,PGM5,PPA1B,HPRT1,PRPS2,SPHK1 |
Interacting Protein
EYA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EYA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EYA2.
TFAP2A;SIX1;TFAP2C;RBPMS
Resources
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References
- Blevins, MA; Towers, CG; et al. The SIX1-EYA transcriptional complex as a therapeutic target in cancer. EXPERT OPINION ON THERAPEUTIC TARGETS 19:213-225(2015).
- Wang, JL; Wu, Y; et al. Fgf-Signaling-Dependent Sox9a and Atoh1a Regulate Otic Neural Development in Zebrafish. JOURNAL OF NEUROSCIENCE 35:234-244(2015).
