ETV7
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Official Full Name
ets variant 7 -
Overview
The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721). -
Synonyms
ETV7;ets variant 7;ets variant gene 7 (TEL2 oncogene);transcription factor ETV7;TEL 2;TEL2;TEL2 oncogene;TELB;ETS related protein Tel2;Tel related Ets factor;Transcription factor Tel 2;TREF;tel-related Ets factor;ETS-related protein Tel2;ETS translocation variant 7;Ets transcription factor TEL-2b;TEL-2
Recombinant Proteins
- Human
- Zebrafish
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- Mammalian cells
- GST
- His
- Non
- Flag
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ETV7-3542H | Recombinant Human ETV7 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ETV7-5344Z | Recombinant Zebrafish ETV7 | Mammalian Cell | Zebrafish | His |
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| ETV7-6518HCL | Recombinant Human ETV7 293 Cell Lysate | HEK293 | Human | Non |
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| ETV7-4373HF | Recombinant Full Length Human ETV7 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 341 amino acids |
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| ETV7-785HFL | Recombinant Full Length Human ETV7 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| ETV7-875H | Recombinant Human ETV7 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| ETV7-875H-B | Recombinant Human ETV7 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
ETV7 involved in several pathways and played different roles in them. We selected most pathways ETV7 participated on our site, such as Dorso-ventral axis formation,Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ETV7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Dorso-ventral axis formation | GRB2B,NOTCH3,PIWIL2,PIWIL1,NOTCH1,CPEB1A,SPIRE1,NOTCH1A,PPP1R2P9,NOTCH2 |
| Transcriptional misregulation in cancer | SIX1,BCL2L1,TP53,JMJD1C,CD86,ETV6,KLF3,TCF3,GOLPH3,CCNT1 |
Protein Function
ETV7 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,protein binding,transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ETV7 itself. We selected most functions ETV7 had, and list some proteins which have the same functions with ETV7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II regulatory region sequence-specific DNA binding | LMO2,IRF2,ZIK1,ZNF711,TFAP2C,ZNF548,GLIS1,MEF2C,PHOX2B,ATF6 |
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | DMBX1,SATB1,ETV6,ETV3,HES6,BCL6A,NR2F6,ZBTB12.2,ISX,ESX1 |
| protein binding | CCL28,SZL,MRPS6,NPHS1,ISG20L2,MRPL41,FAM13C,METTL17,RXFP1,NPHP3 |
Interacting Protein
ETV7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ETV7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ETV7.
VTN;LRPAP1;RICTOR;RPTOR
Resources
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References
- Bisio, A; Zamborszky, J; et al. Cooperative interactions between p53 and NF kappa B enhance cell plasticity. ONCOTARGET 5:12111-12125(2014).
- Hang, BL; Sang, JJ; et al. Transcription analysis of the response of chicken bursa of Fabricius to avian leukosis virus subgroup J strain JS09GY3. VIRUS RESEARCH 188:8-14(2014).
