ETV2
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Official Full Name
ets variant 2 -
Overview
ETV2 is a member of the ETS family of transcription factors. It has been proposed that ETV2 acts downstream of BMP, notch and wnt signalling in blood and vessel specification. ER71 has also shown to be important for Flk1 expression as well as hematopoietic and vascular development. -
Synonyms
ETV2;ets variant 2;ER71;ETSRP71;ETS translocation variant 2;ets variant gene 2;ets-related protein 71
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ETV2-283H | Recombinant Human ETV2 Protein, His-tagged | E.coli | Human | His |
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| ETV2-3504Z | Recombinant Zebrafish ETV2 | Mammalian Cell | Zebrafish | His |
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| ETV2-3533H | Recombinant Human ETV2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ETV2-5350M | Recombinant Mouse ETV2 Protein | Mammalian Cell | Mouse | His |
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| ETV2-932H | Recombinant Human ETV2 | Mammalian Cell | Human | His |
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| ETV2-2881M | Recombinant Mouse ETV2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ETV2-2881M-B | Recombinant Mouse ETV2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| ETV2-2887H | Recombinant Human ETV2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| ETV2-2887H-B | Recombinant Human ETV2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| ETV2-4366HF | Recombinant Full Length Human ETV2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 342 amino acids |
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Involved Pathway
ETV2 involved in several pathways and played different roles in them. We selected most pathways ETV2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ETV2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
ETV2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ETV2 itself. We selected most functions ETV2 had, and list some proteins which have the same functions with ETV2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | HIST2H3A,NFIB,HOXC11,CARF,POU4F3,ZBTB7A,NRF1,ETS2,TFAP2A,KLF16 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | RUNX2,CC2D1B,SOX14,TP53,HIF1AL2,SIM1,KLF11,OVOL2,FOXA3,OVOL1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | RBPJ,ETV1,TFAP2B,GATA2,LEF1,CRX,HNF1A,ONECUTL,EGR2,TFE3A |
Interacting Protein
ETV2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ETV2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ETV2.
Resources
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References
- Morita, R; Suzuki, M; et al. ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:160-165(2015).
- Davis, JA; Desai, SP; et al. ETS Transcription Factor Etsrp/Etv2 Is Required for Lymphangiogenesis in Zebrafish and Is a Potential Therapeutic Target in Lymphatic Disease. BLOOD 124:-(2014).
