ERCC6
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Official Full Name
excision repair cross-complementing rodent repair deficiency, complementation group 6 -
Overview
This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The protein has ATP-stimulated ATPase activity; there are contradictory publications reporting presence or absence of helicase activity. The protein appears to interact with several transcription and excision repair proteins, and may promote complex formation at repair sites. Mutations in this gene result in Cockayne syndrome type B. -
Synonyms
ERCC6;excision repair cross-complementing rodent repair deficiency, complementation group 6;CSB;CKN2;COFS;ARMD5;COFS1;RAD26;DNA excision repair protein ERCC-6;Rad26 homolog;Cockayne syndrome B protein;ATP-dependent helicase ERCC6;cockayne syndrome protein CSB;Cockayne syndrome group B protein;OTTHUMP00000019581;EC 3.6.4.-;EC 3.6.1
Recombinant Proteins
- Human
- Mouse
- Wheat Germ
- E.coli
- HEK293
- HEK293T
- Non
- His
- GST
- Myc&DDK
- His&T7
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ERCC6-26417TH | Recombinant Human ERCC6 | Wheat Germ | Human | Non | 100 amino acids |
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| ERCC6-2672H | Recombinant Human ERCC6, His-tagged | E.coli | Human | His |
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| ERCC6-3461H | Recombinant Human ERCC6 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| Ercc6-1435M | Recombinant Mouse Ercc6 Protein, His-tagged | E.coli | Mouse | His | Gln13-Tyr179 |
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| ERCC6-2113H | Recombinant Human ERCC6 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| ERCC6-2114H | Recombinant Human ERCC6 Protein, His&T7-tagged | E.coli | Human | His&T7 | Val843~Tyr1002 |
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| Ercc6-2855M | Recombinant Mouse Ercc6 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| ERCC6-4775H | Recombinant Human ERCC6 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
ERCC6 involved in several pathways and played different roles in them. We selected most pathways ERCC6 participated on our site, such as Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nucleotide Excision Repair | INO80C,COPS6,ERCC4,GTF2H3,ERCC1,RAD23B,KIAA1530,POLD2,COPS8,INO80B |
Protein Function
ERCC6 has several biochemical functions, for example, ATP binding,DNA binding,NOT DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC6 itself. We selected most functions ERCC6 had, and list some proteins which have the same functions with ERCC6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein N-terminus binding | MNAT1,NFE2,DAXX,STX5A,ERCC2,PDLIM5,PDCD10,TP53,EXOC4,THAP7 |
| DNA-dependent ATPase activity | MSH5,CHD8,SMARCAL1,XRCC3,IGHMBP2,RAD51L1,MSH2,RAD51C,CDK7,ERCC2 |
| DNA binding | PHC2,ZNF286A,TRIM28,SMYD1,ZNF484,SOX3,H2AFB1,HUWE1,ZNF41,PHC3 |
| protein complex binding | SIX2,IST1,FYB,CCNE1,Apba1,TUB,CDK4,CEBPA,MYC,NCK2 |
| NOT DNA helicase activity | ERCC8,DNA2 |
| protein tyrosine kinase activator activity | ABI1,GAS6,Cd24a,GHRL,ERBB3,ABI3A,PAK2,NRG1,CD24,ABI1B |
| protein binding | SEMA3E,SOD1,SPOP,ACD,C2orf51,TALDO1,MRPL27,RGR,SCYL1,ICA1L |
| protein C-terminus binding | PCGF1,RBFOX1,SLC4A1,ERBB2,ERCC4,PQBP1,ATXN2,DBNL,SREBF2,CEP135 |
| ATP binding | HSPA1A,GMPS,NLRP4B,KIF3A,DYRK1A,PSMC1,KIF14,EPHB4B,WNK1,TNNI3K |
Interacting Protein
ERCC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC6.
ERCC8;POLR2A;XAB2;NFKB1;RNF11;Srp72;CBX4;NOP56;CDK2AP1;Eif3a;RPL10;HNRNPU;BAX;HDAC1;Naa50;Rpl35;Mta1
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