EPRS
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Official Full Name
glutamyl-prolyl-tRNA synthetase -
Overview
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. -
Synonyms
EPRS;glutamyl-prolyl-tRNA synthetase;QARS, QPRS;bifunctional glutamate/proline--tRNA ligase;EARS;GLUPRORS;glutamate tRNA ligase;PARS;proline tRNA ligase;proline-tRNA ligase;prolyl-tRNA synthetase;glutaminyl-tRNA synthetase;proliferation-induci
Recombinant Proteins
- Human
- Chicken
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293T
- HEK293
- GST
- His
- His&T7
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EPRS-12504H | Recombinant Human EPRS, GST-tagged | E.coli | Human | GST | C-term-350a.a. | |
| EPRS-3461H | Recombinant Human EPRS protein, His-tagged | E.coli | Human | His | 1163-1512 aa | |
| EPRS-1540C | Recombinant Chicken EPRS | Mammalian Cell | Chicken | His |
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| EPRS-5264M | Recombinant Mouse EPRS Protein | Mammalian Cell | Mouse | His |
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| EPRS-8223H | Recombinant Human EPRS protein, His & T7-tagged | E.coli | Human | His&T7 | Asp749~Thr956 |
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| Eprs-8224M | Recombinant Mouse Eprs protein, His & T7-tagged | E.coli | Mouse | His&T7 | Gly1007~Tyr1512 |
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| EPRS-8402Z | Recombinant Zebrafish EPRS | Mammalian Cell | Zebrafish | His |
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| EPRS-2208H | Recombinant Human EPRS Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| EPRS-2826M | Recombinant Mouse EPRS Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| EPRS-2826M-B | Recombinant Mouse EPRS Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Eprs-331M | Recombinant Mouse Eprs Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
EPRS involved in several pathways and played different roles in them. We selected most pathways EPRS participated on our site, such as Porphyrin and chlorophyll metabolism,Aminoacyl-tRNA biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPRS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | AKR1B7,NDUFV2,ST6GAL2A,POLR2I,ASS1,POLR1A,PIK3C2B,DAO.2,SDSL,CMPK2 |
| Aminoacyl-tRNA biosynthesis | VARS,NARS2,TARS2,SARS,YARS,WARS,FARSB,GATB,GARS,DARS2 |
| Porphyrin and chlorophyll metabolism | HMOX2A,UGT1A6A,CPOX,HEPH,HMOX1,HMOX2,PPOX,UGT2A2,UGT2A1,UGT2B15 |
Protein Function
EPRS has several biochemical functions, for example, ATP binding,GTPase binding,RNA stem-loop binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPRS itself. We selected most functions EPRS had, and list some proteins which have the same functions with EPRS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | COMMD3,GGA1,ZNF514,HLA-A,DZIP1,KTN1,FOXC2,IFT57,CBLB,ZNF207 |
| glutamate-tRNA ligase activity | EARS2 |
| GTPase binding | GNB3,GM5506,STOML2,GNB2,PTPRN,RAB3D,HSP90AA1,SPTBN1,RASA1,VPS41 |
| ATP binding | DAPK2,TOR2A,MTHFD1,MAP3K6,CAMK1DB,ERBB4A,PSMC1A,PFKFB2A,NME4,EIF4A1B |
| proline-tRNA ligase activity | PARS2 |
| RNA stem-loop binding | CPEB3,DDX3X,DAZAP1 |
Interacting Protein
EPRS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPRS here. Most of them are supplied by our site. Hope this information will be useful for your research of EPRS.
IARS;HSP90AA1;gag;NFKBIE;IKBKB;MAP3K7;SYNCRIP;ATG12;ETS1;TFE3;MCC;EEF1D
Resources
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References
- Shin, C; Hwang, GS; et al. H-1, C-13 and N-15 resonance assignment of WHEP domains of human glutamyl-prolyl tRNA synthetase. BIOMOLECULAR NMR ASSIGNMENTS 9:25-30(2015).
- Saga, K; Hasegawa, F; et al. Comparative evaluation of wet and dry processes for recovering hydrocarbon from Botryococcus Braunii. APPLIED ENERGY 141:90-95(2015).
