EPB49
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Official Full Name
erythrocyte membrane protein band 4.9 (dematin) -
Overview
Dematin, or EPB49, is an actin-bundling protein originally identified in the erythroid membrane skeleton. Its;actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase and is restored after;dephosphorylation (Rana et al., 1993 (PubMed 8341682)). -
Synonyms
EPB49;erythrocyte membrane protein band 4.9 (dematin);dematin;DMT;FLJ78462;FLJ98848
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EPB49-12480H | Recombinant Human EPB49, His-tagged | E.coli | Human | His | 1-405a.a. | |
| EPB49-3363H | Recombinant Human EPB49 Protein, GST-tagged | Wheat Germ | Human | GST |
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| EPB49-565HCL | Recombinant Human EPB49 cell lysate | Human | Non |
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| EPB49-1429H | Recombinant Human EPB49 Protein, His-tagged | E.coli | Human | His | Met1-Ser269 |
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| EPB49-4274HF | Recombinant Full Length Human EPB49 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 383 amino acids |
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Involved Pathway
EPB49 involved in several pathways and played different roles in them. We selected most pathways EPB49 participated on our site, such as Miscellaneous transport and binding events,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPB49 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Miscellaneous transport and binding events | ADD1,MRS2,NIPAL3,CTNS,MMGT1,MAGT1,ANKH,ADD3B,DMTN,ADD3 |
| Transmembrane transport of small molecules | MIPA,UNC79,SLC28A1,SLC43A2,SLC39A14,SLC43A1B,RHCG,AQP9B,AQP1A.1,SLC1A7A |
Protein Function
EPB49 has several biochemical functions, for example, actin binding,protein binding,protein self-association. Some of the functions are cooperated with other proteins, some of the functions could acted by EPB49 itself. We selected most functions EPB49 had, and list some proteins which have the same functions with EPB49. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NKRF,NFATC1,RALY,IFT27,FARS2,RAB21,Serpina1b,HOMER1,ZNF256,SRPK3 |
| receptor binding | RND1,CADM1,PARK7,PKD2,HLA-B,WNT5B,STRAP,SLC27A2,NRXN1,DECR2 |
| protein self-association | ABCD3,TRIM32,ACVR2A,SLC9A3R1,ZFP639,SYP,TNFAIP3,PCSK9,SHANK3,NKX3 |
| actin binding | ESPN,PALLD,FMNL2,CAPGA,MYH4,TBC1D21,GC,RP2,VMHCL,FER |
| spectrin binding | USH1C,CAMSAP1,STX4A,ADD2,CAMSAP1L1,USH1G,MYO7A,GBP1,PTPRN,UNC13A |
Interacting Protein
EPB49 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPB49 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPB49.
GOLGA2;saicar;PKM;DYNC1LI2;SNRPD2;PTOV1;PROCR;YWHAB
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References
- Chen, L; Brown, JW; et al. The Allosteric Mechanism Induced by Protein Kinase A (PKA) Phosphorylation of Dematin (Band 4.9). JOURNAL OF BIOLOGICAL CHEMISTRY 288:8313-8320(2013).
- Nikolovski, Z; De La Torre, C; et al. Alterations of the erythrocyte membrane proteome and cytoskeleton network during storage - a possible tool to identify autologous blood transfusion. DRUG TESTING AND ANALYSIS 4:882-890(2012).
