EMX2
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Official Full Name
empty spiracles homeobox 2 -
Overview
This gene encodes a homeobox-containing transcription factor that is the homolog to the empty spiracles gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins. -
Synonyms
EMX2;empty spiracles homeobox 2;empty spiracles homolog 2 (Drosophila);homeobox protein EMX2;empty spiracles homolog 2;empty spiracles-like protein 2
Recombinant Proteins
- Rhesus macaque
- Human
- Mouse
- Zebrafish
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EMX2-1469R | Recombinant Rhesus monkey EMX2 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| EMX2-3296H | Recombinant Human EMX2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| EMX2-5190M | Recombinant Mouse EMX2 Protein | Mammalian Cell | Mouse | His |
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| EMX2-8872Z | Recombinant Zebrafish EMX2 | Mammalian Cell | Zebrafish | His |
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| EMX2-6604HCL | Recombinant Human EMX2 293 Cell Lysate | HEK293 | Human | Non |
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| EMX2-1294R | Recombinant Rhesus Macaque EMX2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| EMX2-1294R-B | Recombinant Rhesus Macaque EMX2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| EMX2-2783M | Recombinant Mouse EMX2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| EMX2-2783M-B | Recombinant Mouse EMX2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| EMX2-4283HF | Recombinant Full Length Human EMX2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 252 amino acids |
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Involved Pathway
EMX2 involved in several pathways and played different roles in them. We selected most pathways EMX2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with EMX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
EMX2 has several biochemical functions, for example, protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EMX2 itself. We selected most functions EMX2 had, and list some proteins which have the same functions with EMX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | HOXD12A,NFE2L2A,NKX2.4A,IRX2A,PRDM5,HOXC11A,VDR,CHCHD2,ZKSCAN1,GATAD1 |
| protein binding | ILVBL,CC2D1B,EED,ASPSCR1,CEBPB,PTMA,TCF7L1A,FZD3,HSPB11,TLR1 |
Interacting Protein
EMX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EMX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EMX2.
EIF4E
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References
- Brancaccio, M; Pivetta, C; et al. Emx2 and Foxg1 Inhibit Gliogenesis and Promote Neuronogenesis. STEM CELLS 28:1206-1218(2010).
- Ostrer, H; Huang, HY; et al. A cellular study of human testis development. SEXUAL DEVELOPMENT 1:286-292(2007).
