EMR2
-
Official Full Name
egf-like module containing, mucin-like, hormone receptor-like 2 -
Overview
This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 3 on chromosome 19. This protein does not interact with the ligand decay accelerating factor for complement, unlike the related CD97 antigen, and indicates that these very closely related proteins likely have nonredundant functions. This gene results in multiple transcripts encoding distinct isoforms. -
Synonyms
EMR2;egf-like module containing, mucin-like, hormone receptor-like 2;egf like module containing, mucin like, hormone receptor like sequence 2;EGF-like module-containing mucin-like hormone receptor-like 2;CD312;EGF-like module receptor 2;egf-like mod
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EMR2-673H |
Active Recombinant Human EMR2 Protein, His-tagged
|
CHO | Human | His | Gln24-Gln478 |
|
| EMR2-358H | Active Recombinant Human EMR2 protein, hFc-tagged | HEK293 | Human | Fc | Gln24-Thr540 |
|
| EMR2-394H | Active Recombinant Human EMR2 protein, His-tagged | HEK293 | Human | His | Met1-Thr540 |
|
| EMR2-616H | Recombinant Human EMR2 protein, His-tagged | E.coli | Human | His | Asn347~Ser509 |
|
Involved Pathway
EMR2 involved in several pathways and played different roles in them. We selected most pathways EMR2 participated on our site, such as Class B/2 (Secretin family receptors),GPCR ligand binding,GPCRs, Class B Secretin-like, which may be useful for your reference. Also, other proteins which involved in the same pathway with EMR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCRs, Other | S1PR1,GPR18,VMN1R46,CELSR2,VMN1R49,LGR6,RRH,PROKR2,GPR17,GPR132 |
| Signaling by GPCR | GPR4,RGS4,PNOC,RCA2.1,PTH,SOUL3,ADCYAP1B,OXTRL,OXGR1,TAC2 |
| GPCRs, Class B Secretin-like | CALCRL,LPHN1,CD97,CRHR1,ELTD1,CRHR2,ADCYAP1R1,EMR1 |
| Signal Transduction | STARD13,TAS2R7,CCL35.2,RIT2,FGFBP1,ACVR1C,RDH14,CRHR2,RLN2,NOXO1A |
| Class B/2 (Secretin family receptors) | GCGA,SETD6,GHRH,FZD10,EMR4,GCGB,ADM2A,CRHB,GNB5A,CRHR2 |
| GPCR ligand binding | DRD4,ADM2,RAMP2,RAMP3,APLNR,GPR4,PNOCB,AGTR2,CCL27,FZD10 |
Protein Function
EMR2 has several biochemical functions, for example, G-protein coupled receptor activity,calcium ion binding,chondroitin sulfate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EMR2 itself. We selected most functions EMR2 had, and list some proteins which have the same functions with EMR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | AGRN,CRB2A,UMOD,ANXA2,PCDH1GC6,PCDHGC4,F7I,PITPNM2,NCS1A,PLCD1 |
| chondroitin sulfate binding | DPYSL3,AGRN |
| G-protein coupled receptor activity | CXCR4A,GPR56,LPAR5,VALOPB,OR1L6,FZD10,APLNR,PTGER1C,EMR4,VMN1R50 |
Interacting Protein
EMR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EMR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EMR2.
Resources
Related Services
Related Products
References
- Gordon, S; Hamann, J; et al. F4/80 and the related adhesion-GPCRs. EUROPEAN JOURNAL OF IMMUNOLOGY 41:2472-2476(2011).
- de Groot, DM; Vogel, G; et al. Therapeutic Antibody Targeting of CD97 in Experimental Arthritis: the Role of Antigen Expression, Shedding, and Internalization on the Pharmacokinetics of Anti-CD97 Monoclonal Antibody 1B2. JOURNAL OF IMMUNOLOGY 183:4127-4134(2009).
