EML4
-
Official Full Name
echinoderm microtubule associated protein like 4 -
Overview
EML4 is a 120 kDa microtubule-associated WD-repeat protein of the EMAP (echinoderm microtubule-associated protein) family. The expression of EML4 is necessary for correct intracellular microtubule network formation. EML4 protein expression is upregulated -
Synonyms
EML4;echinoderm microtubule associated protein like 4;C2orf2;echinoderm microtubule-associated protein-like 4;ELP120;ROPP120;ropp 120;restrictedly overexpressed proliferation-associated protein;EMAP-4;EMAPL4;FLJ10942;FLJ32318;DKFZp686P18118
Recombinant Proteins
- Human
- Mouse
- Sf9 Insect Cell
- Wheat Germ
- HEK293
- HEK293T
- E.coli
- In Vitro Cell Free System
- GST
- Non
- Myc&DDK
- His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EML4-92H |
Active Recombinant Human EML4, GST-tagged
|
Sf9 Insect Cell | Human | GST | 1-496;1058-end a.a. |
|
| EML4-3285H | Recombinant Human EML4 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| EML4-6608HCL | Recombinant Human EML4 293 Cell Lysate | HEK293 | Human | Non |
|
|
| EML4-1684H | Recombinant Human EML4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
|
|
| EML4-2786H | Recombinant Human EML4 Protein (Met1-Phe580), N-His tagged | E.coli | Human | His | Met1-Phe580 |
|
| Eml4-2814M | Recombinant Mouse Eml4 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
|
| EML4-4246HF | Recombinant Full Length Human EML4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 62 amino acids |
|
Involved Pathway
EML4 involved in several pathways and played different roles in them. We selected most pathways EML4 participated on our site, such as Non-small cell lung cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with EML4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-small cell lung cancer | PRKCB,CASP9,PRKCG,RAF1,ERBB2,ARAF,PIK3R3,PIK3CA,MAPK1,PLCG1 |
Protein Function
EML4 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by EML4 itself. We selected most functions EML4 had, and list some proteins which have the same functions with EML4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | DPH7,MFAP3L,MTMR11,CCDC34,MUC6,C3orf75,WFDC15B,PSG2,CNIH,ATF7IP2 |
Interacting Protein
EML4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EML4 here. Most of them are supplied by our site. Hope this information will be useful for your research of EML4.
NEK6;ARIH2;ARL4D;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;ssrna_ug;TFEB;ILK;Nek9
Resources
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References
- Alese, OB; El-Rayes, BF; et al. Anaplastic lymphoma kinase (ALK) gene alteration in signet ring cell carcinoma of the gastrointestinal tract. THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY 7:56-62(2015).
- Xiao, ZG; Sperl, B; et al. Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status. ONCOTARGET 5:12877-12890(2014).
