ELMO1
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Official Full Name
engulfment and cell motility 1 -
Overview
This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] -
Synonyms
ELMO1;engulfment and cell motility 1;CED12;CED-12;ELMO-1;engulfment and cell motility protein 1;ced-12 homolog 1
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Chicken
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ELMO1 involved in several pathways and played different roles in them. We selected most pathways ELMO1 participated on our site, such as Chemokine signaling pathway,Bacterial invasion of epithelial cells,Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ELMO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Shigellosis | CDC42,NFKBIA,IL-8,HCLS1,SRC,WASF1,PFN2,CD44,ARPC5L,MAPK1 |
| Chemokine signaling pathway | CCL15,SHC2,RAC2,CCL22,PREX1,CCL4L1,PIK3CA,CCR3,GNG8,CXCR2 |
| Bacterial invasion of epithelial cells | ARPC2,SHC1,CTTN,VCL,CRK,HCLS1,WASF1,MET,SEPT11,SEPT3 |
Protein Function
ELMO1 has several biochemical functions, for example, SH3 domain binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ELMO1 itself. We selected most functions ELMO1 had, and list some proteins which have the same functions with ELMO1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | HEBP2,GSDMA2,PTPN13,TBX15,LGALS9C,FAM86A,FAM19A1,NFATC4,PAQR5,MYO7A |
| SH3 domain binding | MAPK15,CIT,QKI,SKAP1,QKIA,EVLB,CBL,ARHGAP17,RAD9,VASPA |
Interacting Protein
ELMO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ELMO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ELMO1.
DOCK1;RAC1
ELMO1 Related Signal Pathway
Resources
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References
- Munir, S; Rahman, SB; et al. Association analysis of GWAS and candidate gene loci in a Pakistani population with psoriasis. MOLECULAR IMMUNOLOGY 64:190-194(2015).
- Abu-Thuraia, A; Gauthier, R; et al. Axl Phosphorylates Elmo Scaffold Proteins To Promote Rac Activation and Cell Invasion. MOLECULAR AND CELLULAR BIOLOGY 35:76-87(2015).
