EIF5
-
Official Full Name
eukaryotic translation initiation factor 5 -
Overview
Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of;bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting;functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si;et al., 1996 (PubMed 8663286)). -
Synonyms
EIF5;eukaryotic translation initiation factor 5;eIF-5;EIF-5A
Recombinant Proteins
- Chicken
- Rat
- Human
- Zebrafish
- Mouse
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- His&SUMO
Involved Pathway
EIF5 involved in several pathways and played different roles in them. We selected most pathways EIF5 participated on our site, such as Cap-dependent Translation Initiation,Eukaryotic Translation Initiation,GTP hydrolysis and joining of the 60S ribosomal subunit, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Translation | EEF1G,EIF2B1,APEH,EEF1A2,EEF1D,EEF1B2 |
| RNA transport | SUMO4,NUP214,EIF4G3,EIF1AY,NUP54,UPF1,CLNS1A,FXR1,PABPC4,UBE2IB |
| GTP hydrolysis and joining of the 60S ribosomal subunit | FAUB,EIF4H,EIF3K,EIF4B,EIF2S1,EIF2S1A,EIF4A1,EIF2S3,EIF4A2,EIF1AXA |
| Gene Expression | ZNF445,EEF1E1,ZNF45,ZNF221,EEF1A2,ZNF625,MTA3,ESRRA,FARSB,ZNF670 |
| Metabolism of proteins | SMC6,EXOSC8,PCSK2,EEF1A2,TRAPPC1,MUC15,ST6GAL2B,TBCB,KIFC3,ADAMTS18 |
| Cap-dependent Translation Initiation | EIF4H,EIF2B1,EIF4G1,EIF4A1,FAUB,EIF3K,EIF1AX,EIF2S1,RPL35,EIF4EBP1 |
| Ribosomal scanning and start codon recognition | EIF4H |
| Eukaryotic Translation Initiation | EIF3K,EIF2S1A,EIF2S3,EIF4A2,EIF1AX,FAUB,EIF2B1,RPL35,EIF1AXA,EIF2S1 |
Protein Function
EIF5 has several biochemical functions, for example, GTP binding,GTPase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF5 itself. We selected most functions EIF5 had, and list some proteins which have the same functions with EIF5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | RRAGD,ARL5B,DNM3,RHOF,ARF4A,RABL5,RHOA,OPA1,TUBA7L,RHOUA |
| translation initiation factor activity | EIF3S10,EIF3HA,EIF1AX,EIF3J,EIF4A1,EIF1AXA,GTPBP1L,EIF2D,GTPBP2,EIF4G1 |
| poly(A) RNA binding | TUFM,PRPF4B,SNRNP40,DAZAP1,LSM2,RPL19,GTF2F1,FXR1,DDX49,EIF3L |
| protein binding | C6orf211,NUAK2,SERPINB3C,NEK6,COX4I2,TRIM10,ADAMTS5,HSPA9,SIM1,MCPH1 |
| GTPase activity | DNM2,RHOT1A,RAB9B,RAB41,GNAQ,NKIRAS1,RAB24,GNA13A,DNAJC27,GNG5 |
| translation factor activity, RNA binding | GTF2H3,EIF1AX,CPEB4,GTF2H2,EIF2S2,CPEB2,EIF2S3,CPEB1,EIF4G2,EEF1D |
Interacting Protein
EIF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF5.
DUSP12;EIF1AX;IKBKE;HSPB1;PUM1;ptrB;NRGN;DDX3X;FN1
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