EIF4G2

  • Official Full Name

    eukaryotic translation initiation factor 4 gamma, 2

  • Overview

    Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation;factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The;protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for;eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports;cap-dependent and independent translation, this gene product functions as a general repressor of translation by;forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA;initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms;of this gene have been described.

  • Synonyms

    EIF4G2;eukaryotic translation initiation factor 4 gamma, 2;eukaryotic translation initiation factor 4 gamma 2;DAP5;NAT1;p97;DAP-5;eIF4G 2;eIF-4G 2;eIF-4-gamma 2;aging-associated protein 1;death-associated protein 5;eukaryotic translation initi

Recombinant Proteins

  • Human
  • Chicken
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
EIF4G2-3683H Recombinant Human EIF4G2 protein, His-tagged E.coli Human His 563-907 aa
EIF4G2-3211H Recombinant Human EIF4G2 Protein, GST-tagged Wheat Germ Human GST
EIF4G2-3423C Recombinant Chicken EIF4G2 Mammalian Cell Chicken His
EIF4G2-3725C Recombinant Chicken EIF4G2 Mammalian Cell Chicken His
EIF4G2-5115M Recombinant Mouse EIF4G2 Protein Mammalian Cell Mouse His
EIF4G2-6646HCL Recombinant Human EIF4G2 293 Cell Lysate HEK293 Human Non
EIF4G2-2725M Recombinant Mouse EIF4G2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
EIF4G2-2725M-B Recombinant Mouse EIF4G2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    EIF4G2 involved in several pathways and played different roles in them. We selected most pathways EIF4G2 participated on our site, such as Antiviral mechanism by IFN-stimulated genes,Cytokine Signaling in Immune system,Diurnally regulated genes with circadian orthologs, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4G2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Diurnally regulated genes with circadian orthologs ERC2,QK,STBD1,ITM2B,CEBPB,DAZAP2,PURA,SF3A3,UCP3,KLF9
    Interferon Signaling TRIM17,TRIM46,IFIT12,ADAR,EIF4G2A,ARIH1,EIF4E3,TRIM26,IFI6,TRIM45
    Antiviral mechanism by IFN-stimulated genes IFIT14,EIF4E,KPNA4,IFIT11,EIF4A2,ARIH1L,EIF4A1,IFIT8,UBE2L6,KPNA3
    ISG15 antiviral mechanism IFIT14,UBE2L6,ARIH1,KPNA3,KPNA5,IFIT8,EIF4G2A,MX2,ARIH1L,KPNA4
    Cytokine Signaling in Immune system CSH1,SPTBN2,CNKSR1,GBP2,ISG20,SPRED2,FGF20A,OASL,GBP5,SPTBN1
    Viral myocarditis HLA-C,HLA-DQA2,RAC2,PRF1,CXADR,CD86,RAC3,HLA-DOA,EIF4G3,SGCD
    Immune System Txn1,TREX1,KLHL21,IFI30,CD200R2,AP1S1,TREML4,TXNIPB,EDAR,IRF9
    RNA transport ALYREF,SUMO2,EIF4EA,PABPC1,NXT1,NUP210,ELAC2,NUP188,RANBP2,GEMIN2

    Protein Function

    EIF4G2 has several biochemical functions, for example, poly(A) RNA binding,protein binding,translation factor activity, RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4G2 itself. We selected most functions EIF4G2 had, and list some proteins which have the same functions with EIF4G2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding SATB1,C10orf18,RPF1,IFNAR1,LHX4,ZNF177,MIA3,SLC25A23,PEX12,TRIP13
    translation factor activity, RNA binding EIF5,EEF1A2,EIF4G1,EIF2S2,EIF4E2,CPEB1B,EIF1AX,EEF1D,PPP1R2P9,SOX11
    translation initiation factor activity EIF4G3,EIF4E1B,EIF2S1,MCTS1,EIF4G1,EIF2S3Y,EIF2S2,DENR,EIF5B,EIF4E3
    poly(A) RNA binding RPS27L,PA2G4,STAU2,FAM120B,DBR1,HIST1H4C,PRPF3,FMR1,MADD,NARG1

    Interacting Protein

    EIF4G2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4G2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4G2.

    EIF4A1;EIF2S2;EIF4A2;HSPB1;EIF2S1;Dlg4;EIF3H;PTP4A3;EIF3J;CIAO1;MAGEA6

    EIF4G2 Related Signal Pathway

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