EIF3A
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Official Full Name
eukaryotic translation initiation factor 3, subunit A -
Overview
Eukaryotic translation initiation factor 3 subunit A is a protein that in humans is encoded by the EIF3A gene. EIF3A has been shown to interact with EIF3EIP, EIF4B, DISC1, FBXO32, EIF3D, EIF3C, EIF4G2, EIF3B, EIF3J, EIF3S6, EIF3F, EIF3G, EIF3H, EIF3I and EIF3K. -
Synonyms
eif3a;eukaryotic translation initiation factor 3, subunit A;ncl;eif3;tif32;eif3s10;Nucleolin;eIF3-p170;eif3-theta;nucleolin;Eukaryotic translation initiation factor 3 subunit 10;oocyte nuclear protein
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- His&T7
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EIF3A-3012H | Recombinant Human EIF3A protein, His-tagged | E.coli | Human | His | 266-437 aa | |
| Eif3a-1929M | Recombinant Mouse Eif3a protein, His & T7-tagged | E.coli | Mouse | His&T7 | Glu622~Val848 |
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| EIF3A-2055R | Recombinant Rat EIF3A Protein | Mammalian Cell | Rat | His |
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| EIF3A-3177H | Recombinant Human EIF3A Protein, GST-tagged | Wheat Germ | Human | GST |
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| EIF3A-5091M | Recombinant Mouse EIF3A Protein | Mammalian Cell | Mouse | His |
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| EIF3A-6664HCL | Recombinant Human EIF3A 293 Cell Lysate | HEK293 | Human | Non |
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| EIF3A-1712R | Recombinant Rat EIF3A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| EIF3A-1712R-B | Recombinant Rat EIF3A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| EIF3A-2708M | Recombinant Mouse EIF3A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| EIF3A-2708M-B | Recombinant Mouse EIF3A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| EIF3A-4239HF | Recombinant Full Length Human EIF3A Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 75 amino acids |
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Involved Pathway
EIF3A involved in several pathways and played different roles in them. We selected most pathways EIF3A participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | EIF4BB,DDX39B,ALYREF,NUP153,EIF4E2RS1,NDC1,EIF4E2,EIF3S10,EIF4G1A,THOC4 |
Protein Function
EIF3A has several biochemical functions, for example, poly(A) RNA binding,protein binding,structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF3A itself. We selected most functions EIF3A had, and list some proteins which have the same functions with EIF3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MRPL20,PIKFYVE,ATPAF1,GOLGA2,SLC25A18,MTCH1,MAPKAPK2,NKAP,STK3,SASS6 |
| poly(A) RNA binding | NIP7,GDI2,ASS1,RPL6,CCDC47,SLBP,RAVER1,DNM1,PNPT1,CCAR1 |
| contributes_to translation initiation factor activity | EIF3H,EIF3M,EIF3I,EIF3B,EIF3HA,EIF3D,EIF3EB,EIF2B4,EIF2B3,EIF3K |
| structural molecule activity | SPRR2G,KRT97,LCE3E,LCE1F,TUBG2,NUMA1,MTAP7D2,KRT76,LAMC3,KRTT1C19E |
Interacting Protein
EIF3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF3A here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF3A.
EIF3B;EIF4B;UPF1;EIF3H;KRT7;EIF3F
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References
- Yin, JY; Meng, XG; et al. Association of positively selected eIF3a polymorphisms with toxicity of platinum-based chemotherapy in NSCLC patients. ACTA PHARMACOLOGICA SINICA 36:375-384(2015).
- Aylett, CHS; Boehringer, D; et al. Structure of a Yeast 40S-eIF1-eIF1A-eIF3-eIF3j initiation complex. NATURE STRUCTURAL & MOLECULAR BIOLOGY 22:269-271(2015).
