EIF1AX
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Official Full Name
eukaryotic translation initiation factor 1A, X chromosome -
Overview
Eukaryotic translation initiation factor 1A, X-chromosomal is a protein that in humans is encoded by the EIF1AX gene. Mammalian 17-kDa eukaryotic initiation factor, eIF1A (formerly designated eIF-4C), is essential for transfer of the initiator Met-tRNAf (as Met-tRNAf·eIF2·GTP ternary complex) to 40 S ribosomal subunits in the absence of mRNA to form the 40 S preinitiation complex (40 S·Met-tRNAf·eIF2·GTP). Furthermore, eIF1A acts catalytically in this reaction to mediate highly efficient transfer of the Met-tRNAf·eIF2·GTP ternary complex to 40 S ribosomal subunits. The 40 S complex formed is free of eIF1A which indicates that its role in 40 S preinitiation complex formation is not to stabilize the binding of Met-tRNAf to 40 S ribosomes. Additionally, the eIF1A-mediated 40 S initiation complex formed in the presence of AUG codon efficiently joins 60 S ribosomal subunits in an eIF5-dependent reaction to form a functional 80 S initiation complex. Though found in some reports, eIF1A probably plays no role either in the subunit joining reaction or in the generation of ribosomal subunits from 80 S ribosomes. The major function of eIF1A is to mediate the transfer of Met-tRNAf to 40 S ribosomal subunits to form the 40 S preinitiation complex. -
Synonyms
EIF1AX;eukaryotic translation initiation factor 1A, X chromosome;EIF1A;EIF4C
Recombinant Proteins
- Human
- Rhesus macaque
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E. coli
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
EIF1AX involved in several pathways and played different roles in them. We selected most pathways EIF1AX participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,Cap-dependent Translation Initiation,Eukaryotic Translation Initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF1AX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Formation of the ternary complex, and subsequently, the 43S complex | EIF1AXA,EIF2S1,FAUB,EIF2S1A,EIF2S3,EIF3K |
| Cap-dependent Translation Initiation | EIF2S3,EIF4A1,EIF4EBP1,EIF5,EIF1AXA,EIF4G1,EIF2S1A,FAUB,EIF2S1,EIF4B |
| Gene Expression | SMARCA5,DDX6,FAM36A,MBD3A,NR1D2B,NFIX,SIN3B,TDRD1,PLD6,SEC61B |
| L13a-mediated translational silencing of Ceruloplasmin expression | EIF1AXA,EIF2S1A,EIF3K,EIF4H,EIF2S3,FAUB |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | EIF4H,EIF4A2,EIF4G1,EIF1AXA,EIF2S1,EIF2S3,EIF4E,EIF4EB,EIF3K,EIF4B |
| GTP hydrolysis and joining of the 60S ribosomal subunit | FAUB,EIF4H,EIF4A2,EIF2S1A,EIF2S3,EIF4A1,EIF2S1,RPL35,EIF5,EIF1AXA |
| Formation of a pool of free 40S subunits | RPL35,FAUB,EIF1AXA,EIF3K |
| Eukaryotic Translation Initiation | EIF3K,EIF2S1A,EIF5,EIF4A2,RPL35,EIF1AXA,EIF2B1,EIF4A1,EIF4H,EIF4B |
Protein Function
EIF1AX has several biochemical functions, for example, poly(A) RNA binding,protein binding,translation factor activity, RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF1AX itself. We selected most functions EIF1AX had, and list some proteins which have the same functions with EIF1AX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | ABCF1,SMC1A,ILF2,HDLBP,MKI67,RBFOX2,DKC1,EIF4H,LARP7,PRPF3 |
| translation factor activity, RNA binding | EIF4E2,EIF5,EEF1A2,EIF1,EIF2S3,MTIF3,GTF2H2,CPEB1A,EIF2S2,CPEB2 |
| protein binding | UNC119B,SERP2,RAB7,VEZT,MOCOS,CCNB1,CDT1,C7orf25,UBE2M,HIST1H4C |
| translation initiation factor activity | GTPBP2,EIF2S3,EIF1,MCTS1,EIF2S1A,EIF4EA,MTIF3,GTPBP1,EIF3J,EIF4G1 |
Interacting Protein
EIF1AX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF1AX here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF1AX.
IPO13;RAN;EIF5;EIF1B
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References
- Agrawal, N; Akbani, R; et al. Integrated Genomic Characterization of Papillary Thyroid Carcinoma. CELL 159:676-690(2014).
- Yu, CP; Luo, CC; et al. Molecular network including eIF1AX, RPS7, and 14-3-3 gamma regulates protein translation and cell proliferation in bovine mammary epithelial cells. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 564:142-155(2014).
