EFEMP2
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Official Full Name
EGF containing fibulin-like extracellular matrix protein 2 -
Overview
A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011] -
Synonyms
EFEMP2;EGF containing fibulin-like extracellular matrix protein 2;MBP1;UPH1;FBLN4;ARCL1B;EGF-containing fibulin-like extracellular matrix protein 2;FIBL-4;fibulin 4;fibulin-4;mutant p53 binding protein 1
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His&GST
- His
- GST
- His&T7
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EFEMP2-229H | Recombinant Human EFEMP2 Protein, His/GST-tagged | E.coli | Human | His&GST | Ser26~Phe443 | |
| Efemp2-233M | Recombinant Mouse Efemp2 Protein, His-tagged | E.coli | Mouse | His | Gly182~Val431 | |
| EFEMP2-3086H | Recombinant Human EFEMP2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| EFEMP2-52H | Recombinant Human EFEMP2 protein, T7/His-tagged | E.coli | Human | His&T7 | 26-443 a.a. |
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| EFEMP2-6704HCL | Recombinant Human EFEMP2 293 Cell Lysate | HEK293 | Human | Non |
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| EFEMP2-2107H | Recombinant Human EFEMP2 Protein (Ser26-Phe443), N-GST tagged | E.coli | Human | GST | Ser26-Phe443 |
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| EFEMP2-2494H | Recombinant Human EFEMP2 protein(31-120 aa), C-His-tagged | E.coli | Human | His | 31-120 aa |
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| EFEMP2-4184HF | Recombinant Full Length Human EFEMP2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 229 amino acids |
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Involved Pathway
EFEMP2 involved in several pathways and played different roles in them. We selected most pathways EFEMP2 participated on our site, such as Elastic fibre formation,Extracellular matrix organization,Molecules associated with elastic fibres, which may be useful for your reference. Also, other proteins which involved in the same pathway with EFEMP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Elastic fibre formation | MFAP1B,MFAP3,BMP10,FBLN2,LOXL4,FURINB,LOXL1,ITGB3A,ABHD1,FURINA |
| Extracellular matrix organization | P3H2,MGC174152,ADAMTS4,COL6A2,CMA1,COL28A1,COL9A1A,F11R.2,NID1,LEPREL2 |
| Molecules associated with elastic fibres | MFAP4,LTBP3,MFAP1,MFAP1B,FBLN1,FBLN2,MFAP5,EFEMP1,BMP10,LTBP2 |
Protein Function
EFEMP2 has several biochemical functions, for example, calcium ion binding,extracellular matrix structural constituent,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EFEMP2 itself. We selected most functions EFEMP2 had, and list some proteins which have the same functions with EFEMP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| extracellular matrix structural constituent | COL4A3,LUM,KAL1,COL11A1B,MEPE,COL4A4,MATN3,COL4A5,COL4A1,LAMA1 |
| protein binding | CEP290,NSMCE2,RARRES2,CPSF4,TRIM13,AP2S1,SESTD1,PAN3,GRAP2,GSTA2 |
| calcium ion binding | PCDH15,ANXA11B,NKD2A,DSC2,SNCB,OCM,FSTL4,RCN1,VSNL1A,CALM3 |
Interacting Protein
EFEMP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EFEMP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EFEMP2.
SGTA;SGTB;ELN;FBN1;FBLN5;LOX
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References
- Liu, Y; Wei, J; et al. Proteomic analysis of endothelial progenitor cells exposed to oxidative stress. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 32:607-614(2013).
- Kehrmann, A; Truong, H; et al. Complementation of non-tumorigenicity of HPV18-positive cervical carcinoma cells involves differential mRNA expression of cellular genes including potential tumor suppressor genes on chromosome 11q13. CANCER GENETICS 206:279-292(2013).
