EDEM1
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Official Full Name
ER degradation enhancer, mannosidase alpha-like 1 -
Overview
ER degradation-enhancing alpha-mannosidase-like 1 is an enzyme that in humans is encoded by the EDEM1 gene. -
Synonyms
EDEM1;ER degradation enhancer, mannosidase alpha-like 1;ER degradation-enhancing alpha-mannosidase-like 1;EDEM;KIAA0212;OTTHUMP00000206910;OTTHUMP00000206911
Recombinant Proteins
- Zebrafish
- Chicken
- Rhesus macaque
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- His
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EDEM1-11406Z | Recombinant Zebrafish EDEM1 | Mammalian Cell | Zebrafish | His |
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| EDEM1-1295C | Recombinant Chicken EDEM1 | Mammalian Cell | Chicken | His |
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| EDEM1-1376R | Recombinant Rhesus monkey EDEM1 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| EDEM1-3050H | Recombinant Human EDEM1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| EDEM1-4986M | Recombinant Mouse EDEM1 Protein | Mammalian Cell | Mouse | His |
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| EDEM1-1201R | Recombinant Rhesus Macaque EDEM1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| EDEM1-1201R-B | Recombinant Rhesus Macaque EDEM1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| EDEM1-2637M | Recombinant Mouse EDEM1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| EDEM1-2637M-B | Recombinant Mouse EDEM1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
EDEM1 involved in several pathways and played different roles in them. We selected most pathways EDEM1 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDEM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | RAD23AA,UGGT1,UBXN6,EDEM2,TRAF2,UGGT2,RRBP1,UBQLNL,EIF2AK2,YOD1 |
Protein Function
EDEM1 has several biochemical functions, for example, NOT alpha-mannosidase activity,amylase activity,beta-6-sulfate-N-acetylglucosaminidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EDEM1 itself. We selected most functions EDEM1 had, and list some proteins which have the same functions with EDEM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fucosidase activity | MAN1A |
| glucan endo-1,4-beta-glucosidase activity | MAN1A |
| galactosidase activity | MAN1A |
| misfolded protein binding | DNAJC3,STUB1,HDAC6,HSPD1,BAG6,CLU,DNAJB9,SDF2L1,DNAJC10,HSPA5 |
| protein binding | GTF2I,PRKAB2,RD3,PPP2R5B,PINK1,GYPB,MRC2,ZNF276,LGALS3,C20orf195 |
| amylase activity | AMY2A5,Amy1,MAN1A |
| calcium ion binding | PCDH1G11,PVALB,PCDH2G3,FAT3A,EMR4,PCDHGA6,CDH7,EHD4,SMOC1,PLCD1B |
| dextrin alpha-glucosidase activity | MAN1A |
| glucosidase activity | MAN1A |
Interacting Protein
EDEM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDEM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EDEM1.
DNAJC10;P4HB;PDIA4;HSP90B1;CALR;CANX;PDIA3;PDIA6
Resources
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References
- Sokolowska, I; Pilka, ES; et al. Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells. BMC CELL BIOLOGY 16:-(2015).
- Ninagawa, S; Okada, T; et al. EDEM1/2/3 are alpha 1,2-mannosidases essential for endoplasmic reticulum-associated degradation of glycoproteins. GLYCOBIOLOGY 24:1097-1097(2014).
