DYRK4
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Official Full Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 -
Overview
Dual-specificity kinases, such as DYRK4, play key roles in cell proliferation, survival, and development (Zhang et al.,;2005 (PubMed 15607427)). -
Synonyms
DYRK4;dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4;dual specificity tyrosine-phosphorylation-regulated kinase 4;Dual specificity tyrosine phosphorylation regulated kinase 4;EC 2.7.12.1;OTTHUMP00000238290;OTTHUMP00000238291;OTTHUMP00000238292
Recombinant Proteins
- Human
- E.coli
- Insect Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Insect (sf21)
- His
- Flag
- GST
- Non
- His&Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DYRK4-12240H | Recombinant Human DYRK4, His-tagged | E.coli | Human | His | 104-400a.a. | |
| DYRK4-2992H | Active Recombinant Human DYRK4 Protein, Flag-tagged | Insect Cell | Human | Flag |
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| DYRK4-2993H | Recombinant Human DYRK4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DYRK4-6749HCL | Recombinant Human DYRK4 293 Cell Lysate | HEK293 | Human | Non |
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| DYRK4-0845H | Recombinant Human DYRK4 Protein (M1-V520), Tag Free | Insect Cell | Human | Non | M1-V520 |
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| DYRK4-0846H | Recombinant Human DYRK4 Protein (M1-V520), His/Flag tagged | Insect Cell | Human | His&Flag | M1-V520 |
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| DYRK4-4093HF | Recombinant Full Length Human DYRK4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 520 amino acids |
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| DYRK4-4646HF | Active Recombinant Full Length Human DYRK4 Protein, DYKDDDDK-tagged | Insect (sf21) | Human | Flag | Full L. 1-520(end) |
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Involved Pathway
DYRK4 involved in several pathways and played different roles in them. We selected most pathways DYRK4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DYRK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DYRK4 has several biochemical functions, for example, ATP binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DYRK4 itself. We selected most functions DYRK4 had, and list some proteins which have the same functions with DYRK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine/tyrosine kinase activity | AKT1,RPS6KA1,PRKCG,PRKACA,SGK1,MAP2K1,AURKC,RPS6KB1,DSTYK,TESK2 |
| protein serine/threonine kinase activity | PINK1,GSK3B,CAMK1GB,TGFBR1B,RIPK1,MAST4,MAP3K9,MYO3A,PKN1,LATS1 |
| protein tyrosine kinase activity | ZNF143B,FGFR3,FGR,PTK2AB,INSRA,NTRK3A,EPHB2,FYNA,TESK1,EPHB2B |
| protein binding | Cd79b,NUP50,SHE,MELK,PCP4,USP46,GATA2,SNX27,TFG,C9orf86 |
| ATP binding | MAGI3,DTYMK,CKM,HSPH1,FKBP4,DNAJA3A,TTF2,NEK4,AKT2L,GCLC |
| metal ion binding | EXT1C,ZNF621,SMAD9,RASA4,ATP2A2B,SNAI1A,FGG,TRIM35-1,SAR1B,ZNF354B |
Interacting Protein
DYRK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DYRK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DYRK4.
DYRK2;MID1;HSP90AA1;HSP90AB1;PPP1CC;CUL3;CDIPT;ATP1A1;USP11;RCN1;YME1L1;WDR33;TECR
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References
- Schmitt, C; Miralinaghi, P; et al. Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4. ACS MEDICINAL CHEMISTRY LETTERS 5:963-967(2014).
- Barallobre, MJ; Perier, C; et al. DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson's disease. CELL DEATH & DISEASE 5:-(2014).
