DUSP6
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Official Full Name
dual specificity phosphatase 6 -
Overview
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
DUSP6;dual specificity phosphatase 6;dual specificity protein phosphatase 6;MKP 3;PYST1;MAP kinase phosphatase 3;dual specificity protein phosphatase PYST1;serine/threonine specific protein phosphatase;mitogen-activated protein kinase phosphatase
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Chicken
- Zebrafish
- Insect Cells
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi&Fc&His
- DDK&Myc
- His&Myc
Involved Pathway
DUSP6 involved in several pathways and played different roles in them. We selected most pathways DUSP6 participated on our site, such as ARMS-mediated activation,Activated TLR4 signalling,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activated TLR4 signalling | MAP3K8,IRAK3,RIPK3,APPB,PELI3,SAA1,DHX9,S100B,TIRAP,TICAM1 |
| Developmental Biology | AP2B1,FGF8B,CDK19,SEMA3AA,KBTBD7,SEMA3AB,GFRA2,PHB,GFRA1,AP2S1 |
| B Cell Receptor Signaling Pathway | PIK3AP1,IKBKB,SLA2,MAPK3,RASGRP3,ACTR2,DOK3,PIK3R1,LIME1,NFATC2 |
| DAP12 interactions | PEA15A,DUSP5,SPNA2,PRKAR1AA,PTPRA,FGF20A,FGF8B,DUSP7,CD300E,FRS2A |
| DAP12 signaling | CSF2RA,SPTB,FGF20A,SPTBN2,SPRED2,FRS3,PEA15A,NRG2A,JAK1,FRS2A |
| Cytokine Signaling in Immune system | WDR83,UBE2V1,SPTB,IFIT14,NUPL2,GBP1,KBTBD7,RASGRP4,NEFLB,SPRED1 |
| ARMS-mediated activation | PSME3,DUSP2,FGF18B,DUSP7,CRK,FRS2B,WDR83,CSF2,RASGEF1A,PSMD5 |
| Axon guidance | LRRC4,PAK4,EPHB1,SEMA3E,ROBO2,RGMA,DPYSL5,COL9A1B,PPP3CC,CXCR4 |
Protein Function
DUSP6 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity,protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP6 itself. We selected most functions DUSP6 had, and list some proteins which have the same functions with DUSP6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine phosphatase activity | EPM2A,DUSP21,DUSP23B,MTMR7B,PTPN22,CDC14AB,CDC25C,DUSP7,PTPN3,PTPN4B |
| MAP kinase tyrosine/serine/threonine phosphatase activity | DUSP7,CTDSPL2B,DUSP9,PXYLP1,NT5DC3,SACM1LB,DUSP4,CTDSPL2A,DUSP10,SACM1L |
Interacting Protein
DUSP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP6.
SRPK1;MAPK3;MAPK1;TEX11;MDFI;ZNF212
Resources
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References
- Boeckx, C; de Beeck, KO; et al. Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins. CANCER LETTERS 354:365-377(2014).
- Dickinson, RJ; Delavaine, L; et al. Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways. JOURNAL OF BIOLOGICAL CHEMISTRY 286:38018-38026(2011).
