DUSP16
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Official Full Name
dual specificity phosphatase 16 -
Overview
This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways. -
Synonyms
DUSP16;dual specificity phosphatase 16;dual specificity protein phosphatase 16;KIAA1700;MAPK phosphatase 7;MKP 7;MKP7;MAPK phosphatase-7;MAP kinase phosphatase 7;mitogen-activated protein kinase phosphatase 7;MKP-7;FLJ36298;FLJ40991;MGC129701
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DUSP16-102H | Recombinant Human DUSP16, GST-tagged | E.coli | Human | GST | ||
| DUSP16-101H | Recombinant Human DUSP16, GST-tagged | Wheat Germ | Human | GST |
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| DUSP16-12442Z | Recombinant Zebrafish DUSP16 | Mammalian Cell | Zebrafish | His |
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Involved Pathway
DUSP16 involved in several pathways and played different roles in them. We selected most pathways DUSP16 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | FGF12,RELB,MKNK2A,RRAS2,MAP2K2,TGFBR1A,MAP3K12,MAX,MAPK12B,PPP5C |
Protein Function
DUSP16 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity,phosphoprotein phosphatase activity,protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP16 itself. We selected most functions DUSP16 had, and list some proteins which have the same functions with DUSP16. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine phosphatase activity | PTPRU,MTM1,MTMR2,PTPN22,MTMR7A,DUSP22,PTPRR,DUSP13A,PTPN13,MDP1 |
| MAP kinase tyrosine/serine/threonine phosphatase activity | DUSP4,DUSP18,DUSP8A,DUSP7,PTPRQ,SACM1LA,DUSP2,CTDSPL2B,DUSP9,DUSP21 |
| protein tyrosine/serine/threonine phosphatase activity | EPM2A,CDC14B,PTPDC1,CTDSPL2B,DUSP19B,DUSP14,CDC14A,CDC14AA,PTPMT1,DUSP9 |
| phosphoprotein phosphatase activity | PPP2CA,CTDSPL2B,DLGAP5,SSH2,PTPN11B,PTPN23A,PPP1R3B,DUSP22B,PPP1CBL,MTM1 |
Interacting Protein
DUSP16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP16 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP16.
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References
- Park, H; Park, SY; et al. Discovery of Novel DUSP16 Phosphatase Inhibitors through Virtual Screening with Homology Modeled Protein Structure. JOURNAL OF BIOMOLECULAR SCREENING 19:1383-1390(2014).
- Feurstein, S; Rucker, FG; et al. Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype. BMC GENOMICS 15:-(2014).
