DUSP10
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Official Full Name
dual specificity phosphatase 10 -
Overview
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the;phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily;(MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of;this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue;distribution and subcellular localization, and different modes of inducibility of their expression by extracellular;stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization;is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various;tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different;isoforms have been found for this gene. -
Synonyms
DUSP10;dual specificity phosphatase 10;dual specificity protein phosphatase 10;MKP 5;MKP5;map kinase phosphatase 5;dual specificity phosphatase MKP-5;serine/threonine specific protein phosphatase;mitogen-activated protein kinase phosphatase 5;MKP
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
DUSP10 involved in several pathways and played different roles in them. We selected most pathways DUSP10 participated on our site, such as ARMS-mediated activation,ATF-2 transcription factor network,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ARMS-mediated activation | IL17RD,DUSP7,SPRED2,EGF,PTPRA,SPRED1,PEA15,FRS2A,JAK2,DLG4 |
| Developmental Biology | COL9A1B,FRS2B,SPRED1,PHB,KLB,PTPRA,ACTR2,SEMA3AB,MED22,AP2S1 |
| Cytokine Signaling in Immune system | PEBP1,TRIM6,IFIT8,CSHL1,NEFLB,DUSP6,PAQR3A,DUSP7,EDAR,TNFRSF13C |
| DAP12 signaling | DUSP4,LAMTOR2,AGO2,DUSP9,FGF18B,CNKSR1,PAQR3A,DUSP6,FRS2,DAB2IPB |
| Downstream signal transduction | RASGEF1A,PAQR3A,PEBP1,SPTBN1,MARK3,AGO3,THEM4,DAB2IPB,FRS2A,SPRED3 |
| ATF-2 transcription factor network | JDP2,CDK4,CREB1,CBFB,RUVBL2,JUNB,JUN,MAPK14,KAT5,HRK |
| DAP12 interactions | RASGEF1A,GRAP2A,CD300E,WDR83,PAQR3A,PEA15A,FGF20A,SPRED3,DUSP9,IL17RD |
| Axon guidance | SCN8A,NCAN,PLXNA1,EFNB2,Plxna2,SEMA3A,COL6A3,DOCK1,PAK2,COL9A1 |
Protein Function
DUSP10 has several biochemical functions, for example, MAP kinase phosphatase activity,MAP kinase tyrosine/serine/threonine phosphatase activity,phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP10 itself. We selected most functions DUSP10 had, and list some proteins which have the same functions with DUSP10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MAP kinase tyrosine/serine/threonine phosphatase activity | SACM1LA,DUSP2,TENC1,DUSP18,DUSP16,DUSP5,DUSP6,DUSP21,NT5DC3,CTDSPL2B |
| protein tyrosine phosphatase activity | PTPN11,SSH1,DUSP15,EYA1,MTMR7B,EVLA,PTPN2,PTPN1,CDKN3,PTPN13 |
| phosphatase activity | ATP1A1,PTPN4A,DUSP19B,DUSP11,MINPP1A,PTPN4B,DUSP23B,DUSP28,PPP1CC,DUSP3B |
| MAP kinase phosphatase activity | DUSP3B,DUSP3 |
| protein tyrosine/serine/threonine phosphatase activity | PTPRQ,CTDSPL2A,SACM1L,PTP4A2B,DUSP23A,CTDSPL2B,PTEN,PTP4A1,PTP4A2A,DUSP14 |
| phosphoprotein phosphatase activity | PTPRZ1,PPM1DA,PPP3CCB,PPM1NB,PPP3CB,PPP1CAB,CDC25D,TENC1,PPM1E,PPP4CB |
Interacting Protein
DUSP10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP10 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP10.
MAPK9;Mapk14;SNX2;FN1;HTT;RPS11;FHL2;MAPK14;SLX1A;CMTM6
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References
- Manzano, RG; Martinez-Navarro, EM; et al. Microarray phosphatome profiling of breast cancer patients unveils a complex phosphatase regulatory role of the MAPK and PI3K pathways in estrogen receptor-negative breast cancers. INTERNATIONAL JOURNAL OF ONCOLOGY 45:2250-2266(2014).
- Ryynanen, J; Neme, A; et al. Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals. MOLECULAR NUTRITION & FOOD RESEARCH 58:2036-2045(2014).
