DSN1

  • Official Full Name

    DSN1 DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)

  • Overview

    Defects in kinetochore proteins often lead to aneuploidy and cancer. Mis12-Ktw1 is a conserved essential kinetochore protein family. Human Mis13 protein (c20orf172) is one of the several proteins that form Mis12-kinetochore complex and required for chromosome segregation. Mis13 protein also physically interacts with Blinkin/AF15q14 which is required for mitotic checkpoint and chromosome alignment. It is also required for condensin to accumulate at kinetochores.

  • Synonyms

    DSN1;DSN1, MIND kinetochore complex component, homolog (S. cerevisiae);C20orf172, chromosome 20 open reading frame 172;kinetochore-associated protein DSN1 homolog;dJ469A13.2;hKNL 3;kinetochore null 3 homolog (C. elegans);KNL3;MIS13;kinetochore null 3 homolog;hKNL-3;C20orf172;FLJ13346;MGC32987

Recombinant Proteins

  • Rhesus macaque
  • Human
  • Chicken
  • Mouse
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • HEK293T
  • E.coli
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Myc&DDK
  • His&Fc&Avi

    Involved Pathway

    DSN1 involved in several pathways and played different roles in them. We selected most pathways DSN1 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with DSN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RHO GTPase Effectors NDEL1B,CCDC99,RTKN,FMNL2,RHPN2,CIT,MKL1B,SPC25,KLC3,NOXA1
    Cell Cycle, Mitotic CEP70,HIST3H2BB,NUDC,LIN54,NUMA1,CLASP1A,CSNK2A1,DNA2,CDK6,PDS5A
    Mitotic Anaphase SKA1,CENPK,RANGAP1B,LEMD3,CENPO,CENPN,SKA2,NDC80,MLF1IP,NUF2
    RHO GTPases Activate Formins RCC2,AHCTF1,PMF1,NDEL1B,SKA1,EVL,DIAPH1,FMNL1,NUF2,CCDC99
    Cell cycle YWHAE1,BRCC3,CENPP,GADD45B,ANKLE2,YWHABB,TGFB2,PKMYT1,CP110,YWHAH
    M Phase NCAPD2,CENPH,CENPI,NCAPH2,INCENP,VRK2,NDEL1B,SETB,CLIP1,CENPA
    Mitotic Metaphase and Anaphase PDS5B,CENPN,NSL1,NUDC,RANGAP1B,SGOL1,CENPE,TMPO,NDEL1A,CENPO
    Mitotic Prometaphase SKA2,CENPP,CCDC99,SPDL1,MLF1IP,ERCC6L,NSL1,NDEL1B,RANGAP1B,SGOL1

    Protein Function

    DSN1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DSN1 itself. We selected most functions DSN1 had, and list some proteins which have the same functions with DSN1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PPID,CARKD,GAB1,ZFPM1,NOL3,MITF,AP2A2,IL6,TRMT1,ATG101

    Interacting Protein

    DSN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DSN1.

    ZWINT;MIS12;Casc5;Mis12;CBX5;Bub1;BUB1;Zwint;Dsn1

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