DSC1
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Official Full Name
desmocollin 1 -
Overview
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms. -
Synonyms
DSC1;desmocollin 1;desmocollin-1;CDHF1;cadherin family member 1;desmosomal glycoprotein 2/3;DG2/DG3
Recombinant Proteins
- Human
- Mouse
- Mus musculus
- Schizosaccharomyces pombe
- E.coli
- E.coli expression system
- GST
- His
- His&GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DSC1-3706H | Recombinant Human DSC1 protein, GST-tagged | E.coli | Human | GST | 607-689 aa | |
| DSC1-476H | Recombinant Human DSC1 Protein, His-tagged | E.coli | Human | His | Ala486~Asn686 | |
| Dsc1-477M | Recombinant Mouse Dsc1 Protein, His-tagged | E.coli | Mouse | His | Arg135~Ile340 | |
| DSC1-1384H | Recombinant Human DSC1 Protein, His&GST-tagged | E.coli | Human | His&GST | Cys30-Ser353 |
|
| DSC1-2832H | Recombinant Human DSC1 protein(791-870 aa), C-His-tagged | E.coli | Human | His | 791-870 aa |
|
| RFL20506MF | Recombinant Full Length Mouse Desmocollin-1(Dsc1) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length of Mature Protein (135-886) |
|
| RFL528SF | Recombinant Full Length Schizosaccharomyces Pombe Uncharacterized Ring Finger Protein C947.10 (Spbc947.10) Protein, His-Tagged | E.coli expression system | Schizosaccharomyces pombe | His | Full L. Full Length (1-676) |
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Involved Pathway
DSC1 involved in several pathways and played different roles in them. We selected most pathways DSC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DSC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DSC1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DSC1 itself. We selected most functions DSC1 had, and list some proteins which have the same functions with DSC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
DSC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DSC1.
Resources
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References
- Saruta, H; Ishii, N; et al. Two Cases of Pemphigus Vegetans With IgG Anti-Desmocollin 3 Antibodies. JAMA DERMATOLOGY 149:1209-1213(2013).
- Arai, R; Okuda, H; et al. IgA pemphigus with non-pustular erythematous lesions and IgA antibodies to desmocollins 1 and 2. EUROPEAN JOURNAL OF DERMATOLOGY 23:362-365(2013).
