DRAP1
-
Official Full Name
DR1-associated protein 1 (negative cofactor 2 alpha) -
Overview
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans.Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. -
Synonyms
DRAP1;DR1-associated protein 1 (negative cofactor 2 alpha);dr1-associated corepressor;DR1 associated corepressor;NC2 alpha;negative cofactor 2 alpha;DR1 associated protein 1 (negative cofactor 2 alpha);DR1 associated protein 1;DR1 associated protein1;DRAP 1;NC 2 alpha;NC 2alpha;Negative cofactor 2alpha;OTTHUMP00000234061;OTTHUMP00000234062;OTTHUMP00000234063;OTTHUMP00000234065;OTTHUMP00000234066;negative co-factor 2-alpha;NC2-alpha
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Rat
- Human
- Mouse
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DRAP1 involved in several pathways and played different roles in them. We selected most pathways DRAP1 participated on our site, such as Developmental Biology,Signal Transduction,Signaling by Activin, which may be useful for your reference. Also, other proteins which involved in the same pathway with DRAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | LPAR2A,SKIA,TAGAPA,METAP2B,RBP4,SKIB,FMNL1,AKAP13,EVC2,RGS7 |
| Developmental Biology | EBF1,TCF4,MED6,DPYSL5B,MED29,MYOD1,MED19,POU5F3,CRMP1,MED25 |
| Signaling by NODAL | TDGF1,ACVR1C,LEFTY1,CFC1,FOXH1,GDF1,PCSK6 |
| Signaling by Activin | FST,INHBAA,FSTB,FSTL3,FOXH1,ACVR1C |
Protein Function
DRAP1 has several biochemical functions, for example, DNA binding,protein binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DRAP1 itself. We selected most functions DRAP1 had, and list some proteins which have the same functions with DRAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | ADD1,PBX1,SYT10,ROPN1B,EGFR,RARA,H2AFB1,KCNH5,SOX8,IKBKB |
| protein binding | TP53BP1,CIC,MVK,PHF10,MCL1,HSPG2,STAT3,SPATC1,RHOH,CALM1 |
| transcription factor activity, sequence-specific DNA binding | ZFP287,CNBP,FOXC1,HEY1,PBX2,HOXD10,MYCH,NFE2,GATA2A,ZSCAN16 |
| transcription factor binding | FHL2,DACT2,PSMD4,NIF3L1,KAT8,Trl,DAXX,MAPK1,SOX17,PIK3R1 |
| DNA binding | ZHX3,UBN2A,ZFP93,ILF3B,SRFA,HMBOX1,TIGD4,DNA2,LASS2,POLR1E |
| transcription corepressor activity | FEV,JAZF1,KDM5B,ARHGAP35,RELB,RBFOX2,KCNA3,HEYL,TOB1,ZHX2 |
Interacting Protein
DRAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DRAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DRAP1.
TAF9;NFYB;TAF9B;POLE3;LMO2
Resources
Related Services
Related Products
References
- Kantidakis, T; White, RJ; et al. Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells. NUCLEIC ACIDS RESEARCH 38:1228-1239(2010).
- Valdagni, R; Rancati, T; et al. TO BLEED OR NOT TO BLEED. A PREDICTION BASED ON INDIVIDUAL GENE PROFILING COMBINED WITH DOSE-VOLUME HISTOGRAM SHAPES IN PROSTATE CANCER PATIENTS UNDERGOING THREE-DIMENSIONAL CONFORMAL RADIATION THERAPY. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 74:1431-1440(2009).
