DPP8
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Official Full Name
dipeptidyl-peptidase 8 -
Overview
This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] -
Synonyms
DPP8;dipeptidyl-peptidase 8;DP8;DPRP1;MSTP141;dipeptidyl peptidase 8;DPRP-1;DPP VIII;dipeptidylpeptidase 8;prolyl dipeptidase DPP8;dipeptidyl peptidase VIII;dipeptidyl peptidase IV-related protein 1;dipeptidyl peptidase IV-related protein-1
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- Insect Cell
- HEK293T
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DPP8 involved in several pathways and played different roles in them. We selected most pathways DPP8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DPP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DPP8 has several biochemical functions, for example, dipeptidyl-peptidase activity,serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DPP8 itself. We selected most functions DPP8 had, and list some proteins which have the same functions with DPP8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dipeptidyl-peptidase activity | DPEP2,DPEP1,PRCP,NAALAD2,DPP3,DPP7,DPP4,FAP,DPEP3 |
| serine-type peptidase activity | ENDOU,Reln,CFD,HGFA,KLK7,PARLA,HTRA1A,TMPRSS11F,TMPRSS13A,ELA3L |
Interacting Protein
DPP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPP8.
CXCL11;CXCL10;p48061-1;p48061-2
Resources
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References
- Harstad, EB; Rosenblum, JS; et al. DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues. REGULATORY PEPTIDES 186:26-35(2013).
- Justa-Schuch, D; Moller, U; et al. The amino terminus extension in the long dipeptidyl peptidase 9 isoform contains a nuclear localization signal targeting the active peptidase to the nucleus. CELLULAR AND MOLECULAR LIFE SCIENCES 71:3611-3626(2014).
