DPAGT1

  • Official Full Name

    dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)

  • Overview

    The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme.

  • Synonyms

    DPAGT1;dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase);DPAGT, DPAGT2;UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase;ALG7;CDG Ij;D11S366;DGPT;GPT;Gnpta;H2afx;AU021132;Dolichyl phosphate (UDP N acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc 1 P transferase);DPAGT2;G1PT;GlcNAc-1-P transferase;GPT_HUMAN;N-acetylglucosamine-1-phosphate transferase;OTTHUMP00000204052;OTTHUMP00000204055;dolichyl-phosphate alpha-N-acetylglucosaminyltransferase;UDP-GlcNAc:dolichyl-phosphate N-acetylglucosaminephosphotransferase;dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P tra;UAGT;UGAT;CDG1J;DPAGT;CDG-Ij

Recombinant Proteins

  • Rhesus macaque
  • Human
  • Mouse
  • Zebrafish
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
DPAGT1-1316R Recombinant Rhesus monkey DPAGT1 Protein, His-tagged Mammalian Cell Rhesus macaque His
DPAGT1-2822H Recombinant Human DPAGT1 Protein, GST-tagged Wheat Germ Human GST
DPAGT1-4776M Recombinant Mouse DPAGT1 Protein Mammalian Cell Mouse His
DPAGT1-5545Z Recombinant Zebrafish DPAGT1 Mammalian Cell Zebrafish His
DPAGT1-6840HCL Recombinant Human DPAGT1 293 Cell Lysate HEK293 Human Non
DPAGT1-1141R Recombinant Rhesus Macaque DPAGT1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
DPAGT1-1141R-B Recombinant Rhesus Macaque DPAGT1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
DPAGT1-2492M Recombinant Mouse DPAGT1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
DPAGT1-2492M-B Recombinant Mouse DPAGT1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    DPAGT1 involved in several pathways and played different roles in them. We selected most pathways DPAGT1 participated on our site, such as Asparagine N-linked glycosylation,Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPAGT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein MPDU1,ST6GALNAC2,ST8SIA2,NEU4,ST6GAL2B,NANP,SLC35A1,ALG14,MPDU1B,ST8SIA3
    Asparagine N-linked glycosylation SCFD1,ST6GAL2B,ALG14,MPDU1B,SEC22C,SEC23A,MGAT4B,TRAPPC6A,GOLGA2,SLC35A1
    N-Glycan biosynthesis MGAT4C,TUSC3,ALG12,RPN1,B4GALT3,DPM3,DPM2,ALG1,ST6GAL1,MAN2A2
    Post-translational protein modification ADAMTS8,ARSD,ADAMTSL1,GALNTL2,ADAMTS1,ARSK,NANP,PREB,STT3A,ADAMTS15
    Metabolism of proteins KDELR3,CTDSP2,SLC25A12,TMED10,GRPEL2,DPP4,EEF1B2,RHBDL1,TRAPPC6A,ALG2
    Metabolic pathways SMPD2A,GLULC,CYP19A1A,AGPHD1,PNLIPRP3,AOC3,POLE3,MAN1A,ALDH2.2,ACAA1

    Protein Function

    DPAGT1 has several biochemical functions, for example, UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity,phospho-N-acetylmuramoyl-pentapeptide-transferase activity,transferase activity, transferring glycosyl groups. Some of the functions are cooperated with other proteins, some of the functions could acted by DPAGT1 itself. We selected most functions DPAGT1 had, and list some proteins which have the same functions with DPAGT1. You can find most of the proteins on our site.

    Function Related Protein
    transferase activity, transferring glycosyl groups UGT5A1,B3GNT2A,UGT1B7,HPRT1L,B3GNT2B,GLT1D1,PYGMA,GTDC2,UGT8A,UGT5C3

    Interacting Protein

    DPAGT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPAGT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPAGT1.

    MFSD3

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