DOLK
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Official Full Name
dolichol kinase -
Overview
The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency. -
Synonyms
DOLK;dolichol kinase;TMEM15, transmembrane protein 15;DK1;dolichol kinase 1;KIAA1094;CDG1M;DK;SEC59;SEC59, YEAST, HOMOLOG OF;TMEM15;Transmembrane protein 15;SEC59 homolog
Recombinant Proteins
- Rhesus macaque
- Human
- Mouse
- Chicken
- Zebrafish
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DOLK-1314R | Recombinant Rhesus monkey DOLK Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| DOLK-2817H | Recombinant Human DOLK Protein | Wheat Germ | Human | Non |
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| DOLK-4767M | Recombinant Mouse DOLK Protein | Mammalian Cell | Mouse | His |
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| DOLK-5037C | Recombinant Chicken DOLK | Mammalian Cell | Chicken | His |
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| DOLK-6201Z | Recombinant Zebrafish DOLK | Mammalian Cell | Zebrafish | His |
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| DOLK-6842HCL | Recombinant Human DOLK 293 Cell Lysate | HEK293 | Human | Non |
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| DOLK-1139R | Recombinant Rhesus Macaque DOLK Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| DOLK-1139R-B | Recombinant Rhesus Macaque DOLK Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| DOLK-2488M | Recombinant Mouse DOLK Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DOLK-2488M-B | Recombinant Mouse DOLK Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| DOLK-3947HF | Recombinant Full Length Human DOLK Protein | In Vitro Cell Free System | Human | Full L. 289 amino acids |
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Involved Pathway
DOLK involved in several pathways and played different roles in them. We selected most pathways DOLK participated on our site, such as N-Glycan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOLK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | PTGES3A,EARS2,MPST,KDSR,TPO,NDUFA8,MTAP,DGKAA,PIGO,DBH |
| N-Glycan biosynthesis | MOGS,MGAT1A,ALG12,ALG14,MAN1C1,MGAT5B,ALG9,MGAT2,MGAT4C,STT3A |
Protein Function
DOLK has several biochemical functions, for example, dolichol kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOLK itself. We selected most functions DOLK had, and list some proteins which have the same functions with DOLK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LNX1,CYSLTR2,MOXD1,ACVR2A,RADIL,UBE2D2,USF2,FAM9C,ADORA2A,CLPP |
Interacting Protein
DOLK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOLK here. Most of them are supplied by our site. Hope this information will be useful for your research of DOLK.
EDA;CREB3
Resources
Related Services
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References
- Voss, S; Dolk, DR; et al. Interview with Daniel Dolk and Christer Carlsson on "Decision Analytics". BUSINESS & INFORMATION SYSTEMS ENGINEERING 6:181-184(2014).
- Lieu, MT; Ng, BG; et al. Severe, fatal multisystem manifestations in a patient with dolichol kinase-congenital disorder of glycosylation. MOLECULAR GENETICS AND METABOLISM 110:484-489(2013).
