DOK5
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Official Full Name
docking protein 5 -
Overview
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP. -
Synonyms
DOK5;docking protein 5;C20orf180, chromosome 20 open reading frame 180;dJ805C22.1;IRS6;IRS-6;insulin receptor substrate 6;downstream of tyrosine kinase 5;C20orf180;MGC16926
Recombinant Proteins
- Rhesus macaque
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- GST
- Non
- His&Fc&Avi
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DOK5-1312R | Recombinant Rhesus monkey DOK5 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| DOK5-2813H | Recombinant Human DOK5 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DOK5-4764M | Recombinant Mouse DOK5 Protein | Mammalian Cell | Mouse | His |
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| DOK5-6845HCL | Recombinant Human DOK5 293 Cell Lysate | HEK293 | Human | Non |
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| DOK5-1137R | Recombinant Rhesus Macaque DOK5 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| DOK5-1137R-B | Recombinant Rhesus Macaque DOK5 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| DOK5-2485M | Recombinant Mouse DOK5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DOK5-2485M-B | Recombinant Mouse DOK5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| DOK5-3943HF | Recombinant Full Length Human DOK5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 306 amino acids |
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| DOK5-460H | Recombinant Human DOK5 Protein (1-198 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 1-198 aa |
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Involved Pathway
DOK5 involved in several pathways and played different roles in them. We selected most pathways DOK5 participated on our site, such as BDNF signaling pathway,Signaling events regulated by Ret tyrosine kinase, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| BDNF signaling pathway | CSNK2A1P,CDKL5,DPYSL2,SYN1,JAK2,EIF4EBP1,CNR1,CSNK2A1,CDH2,EIF2S1 |
| Signaling events regulated by Ret tyrosine kinase | PDLIM7,GFRA1,GDNF,DOK6,DOK4 |
Protein Function
DOK5 has several biochemical functions, for example, insulin receptor binding,receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DOK5 itself. We selected most functions DOK5 had, and list some proteins which have the same functions with DOK5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor signaling protein activity | FLRT1,TYROBP,TRAIP,IL4R,ARAF,DCLK1,PLCE1,KLK1B4,SMAD1,NCR1 |
| insulin receptor binding | IRS4,INS1,SHC1,PIK3R1,FRS2A,IRS2,DOK2,FRS3,SNX1,DOK1 |
Interacting Protein
DOK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOK5.
EGFR;BNIP3L;OPRM1;CCDC85B
Resources
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References
- Pillai, K; Pourgholami, MH; et al. MUC1 as a Potential Target in Anticancer Therapies. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS 38:108-118(2015).
- Su, CTT; Nguyen, TD; et al. IFACEwat: the interfacial water-implemented re-ranking algorithm to improve the discrimination of near native structures for protein rigid docking. BMC BIOINFORMATICS 15:-(2014).
