DNAJB8
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Official Full Name
DnaJ (Hsp40) homolog, subfamily B, member 8 -
Overview
DNAJB8 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 -
Synonyms
DNAJB8;DnaJ (Hsp40) homolog, subfamily B, member 8;dnaJ homolog subfamily B member 8;MGC33884;DJ6;DNJB8_HUMAN;mDj6;OTTHUMP00000216243;DnaJ homolog, subfamily B, member 8
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- Human
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- His&SUMO
Involved Pathway
DNAJB8 involved in several pathways and played different roles in them. We selected most pathways DNAJB8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DNAJB8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DNAJB8 has several biochemical functions, for example, chaperone binding,protein binding involved in protein folding,unfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DNAJB8 itself. We selected most functions DNAJB8 had, and list some proteins which have the same functions with DNAJB8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chaperone binding | FGB,H2-KE2,BAK1,SERPINA7,HES1,BAG3,DNAJB1,BAG1,SLC25A17,TRP53 |
| protein binding involved in protein folding | CALR3,RIC3,CLGN,CD74,HSPA1A,CALR,PFDN1,PDCL3,HSPA1B,PFDN2 |
| unfolded protein binding | TOMM20,HSPD1,HSP90B1,HSPA5,TBCA,HSP104,DNAJA3,H2-KE2,CLPX,CCT6A |
Interacting Protein
DNAJB8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNAJB8 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNAJB8.
ERBB2
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References
- Yang, P; Huo, ZH; et al. Cancer/Testis Antigens Trigger Epithelial-Mesenchymal Transition and Genesis of Cancer Stem-Like Cells. CURRENT PHARMACEUTICAL DESIGN 21:1292-1300(2015).
- Morita, R; Nishizawa, S; et al. Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells. CANCER SCIENCE 105:389-395(2014).
