DMTF1
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Official Full Name
cyclin D binding myb-like transcription factor 1 -
Overview
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
DMTF1;cyclin D binding myb-like transcription factor 1;cyclin-D-binding Myb-like transcription factor 1;cyclin D binding Myb like protein;DMP1;DMTF;hDMP1;hDMTF1;cyclin D-binding Myb-like protein;cyclin-D-interacting Myb-like protein 1;FLJ25188
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Chicken
- Mouse
- Zebrafish
- Mammalian Cell
- Wheat Germ
- HEK293
- His
- GST
- His&Fc&Avi
Involved Pathway
DMTF1 involved in several pathways and played different roles in them. We selected most pathways DMTF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DMTF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DMTF1 has several biochemical functions, for example, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DMTF1 itself. We selected most functions DMTF1 had, and list some proteins which have the same functions with DMTF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | DBX1A,TBX5A,IRF2,RXRBB,MYCA,POU2F1A,RX1,MED26,MYCL1,ZNF334 |
Interacting Protein
DMTF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DMTF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DMTF1.
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References
- Kobayashi, M; Srour, EF; et al. Regulation of murine hematopoietic stem cell quiescence by Dmtf1. BLOOD 118:6562-6571(2011).
- Golubovskaya, VM; Zheng, M; et al. The direct effect of Focal Adhesion Kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis. BMC CANCER 9:-(2009).
