DKK4
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Official Full Name
dickkopf homolog 4 -
Overview
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. -
Synonyms
DKK4;dickkopf homolog 4 (Xenopus laevis);dickkopf (Xenopus laevis) homolog 4;dickkopf-related protein 4;hDkk-4;dickkopf-4;DKK-4;MGC129562;MGC129563
Recombinant Proteins
- Mouse
- Human
- Mammalian cells
- Wheat Germ
- Mammalian Cell
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- GST
- Non
- His&T7
- His&GST
- His&Fc&Avi
Involved Pathway
DKK4 involved in several pathways and played different roles in them. We selected most pathways DKK4 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DKK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | SFRP1A,FBXW11B,WNT3,PSEN1,CSNK1A1L,DAAM2,DAAM1B,TP53,PPP3CA,NLK2 |
Protein Function
DKK4 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by DKK4 itself. We selected most functions DKK4 had, and list some proteins which have the same functions with DKK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | C21orf62,CTAG2,DEFB37,CCDC34,GRXCR2,SLC6A8,CCDC106A,LRRC8D,ARHGEF39,CEACAM18 |
Interacting Protein
DKK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DKK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DKK4.
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References
- Schon, S; Flierman, I; et al. beta-catenin regulates NF-kappa B activity via TNFRSF19 in colorectal cancer cells. INTERNATIONAL JOURNAL OF CANCER 135:1800-1811(2014).
- Hong, FS; Hong, J; et al. Chronic Exposure to Nanoparticulate TiO2 Causes Renal Fibrosis Involving Activation of the Wnt Pathway in Mouse Kidney. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 63:1639-1647(2015).
