DKC1
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Official Full Name
dyskeratosis congenita 1, dyskerin -
Overview
This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] -
Synonyms
DKC1;dyskeratosis congenita 1, dyskerin;DKC;CBF5;DKCX;NAP57;NOLA4;XAP101;H/ACA ribonucleoprotein complex subunit 4;CBF5 homolog;snoRNP protein DKC1;nucleolar protein NAP57;nucleolar protein family A member 4;nopp140-associated protein of 57 kDa
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Chicken
- Zebrafish
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DKC1-1272R | Recombinant Rhesus monkey DKC1 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| DKC1-1875R | Recombinant Rat DKC1 Protein | Mammalian Cell | Rat | His |
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| DKC1-261H | Recombinant Human DKC1 protein, GST-tagged | Wheat Germ | Human | GST | 1 a.a. - 514 a.a. |
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| DKC1-2787C | Recombinant Chicken DKC1 | Mammalian Cell | Chicken | His |
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| DKC1-3393Z | Recombinant Zebrafish DKC1 | Mammalian Cell | Zebrafish | His |
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| DKC1-6916HCL | Recombinant Human DKC1 293 Cell Lysate | HEK293 | Human | Non |
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| DKC1-1097R | Recombinant Rhesus Macaque DKC1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| DKC1-1097R-B | Recombinant Rhesus Macaque DKC1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| DKC1-1533R | Recombinant Rat DKC1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| DKC1-1533R-B | Recombinant Rat DKC1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| DKC1-570HF | Recombinant Full Length Human DKC1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 514 amino acids |
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| DKC1-685H | Recombinant Human DKC1 Protein, His-tagged | E.coli | Human | His | Arg298~Leu465 |
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| Dkc1-686M | Recombinant Mouse Dkc1 Protein, His-tagged | E.coli | Mouse | His | Arg298~Glu509 |
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| Dkc1-687R | Recombinant Rat Dkc1 Protein, His-tagged | E.coli | Rat | His | Lys298~Gly509 |
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Involved Pathway
DKC1 involved in several pathways and played different roles in them. We selected most pathways DKC1 participated on our site, such as Cell Cycle,Chromosome Maintenance,Extension of Telomeres, which may be useful for your reference. Also, other proteins which involved in the same pathway with DKC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Extension of Telomeres | WRAP53,RUVBL2 |
| Telomere Maintenance | WRAP53 |
| Chromosome Maintenance | ACD,SMARCA5,MIS18BP1,CENPO,OIP5,POT1A,CENPI,CENPH,RUVBL2,ITGB3BP |
| Regulation of Telomerase | NR2F2,CMTM2A,TNKS,PINX1,MXD1,SP3 |
| Cell cycle | ORC2L,MAD1L1,TGFB1,ATM,SMAD3,CENPI,SGOL2,E2F3,VRK2,SKP1 |
| Ribosome biogenesis in eukaryotes | NOP10,FBLL1,XRN1,EIF6,NHP2,WDR36,RBM28,PWP2H,NAT10,NXT1 |
| Telomere Extension By Telomerase | WRAP53 |
Protein Function
DKC1 has several biochemical functions, for example, RNA binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DKC1 itself. We selected most functions DKC1 had, and list some proteins which have the same functions with DKC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | SNRNP70,MRPL3,RNMTL1B,C1D,CWC22,PABPC1A,CNOT4B,DDX51,UPF1,NSUN3 |
| telomerase RNA binding | GAR1,HNRNPC,WRAP53,NOP10,HNRNPU,TERT,PINX1,NHP2 |
| poly(A) RNA binding | COX4I2,UBFD1,TCERG1,RPS27.1,SRSF11,SNW1,REPIN1,EIF5B,TFB1M,CSTF2 |
| telomerase activity | CTU1,PTGES3,UAP1L1,TERT,CCDC111,PRIM2 |
| pseudouridine synthase activity | TRUB2,RPUSD4,PUS7,RPUSD1,PUS7L,RPUSD3,PUSL1,PUS3,RPUSD2,PUS1 |
| protein binding | UBXN8,EDAR,SNRPD3,BCL2L13,PAK1,ACTN2,NPPA,CARD9,DHDDS,POLDIP2 |
Interacting Protein
DKC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DKC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DKC1.
NAF1;WRAP53;RUVBL1
Resources
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References
- Gao, JJ; Roy, S; et al. Arsenic exposure, telomere length, and expression of telomere-related genes among Bangladeshi individuals. ENVIRONMENTAL RESEARCH 136:462-469(2015).
- Cerrudo, CS; Gomez, DLM; et al. Novel Insights into the Evolution and Structural Characterization of Dyskerin Using Comprehensive Bioinformatics Analysis. JOURNAL OF PROTEOME RESEARCH 14:874-887(2015).
Reviews
Q&As
Yes, I did experiments using the DKC1 that I purchased, and I could observe what I expected regarding biological role of DKC1.