DIRAS3
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Official Full Name
DIRAS family, GTP-binding RAS-like 3 -
Overview
This gene is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with monoallelic expression of the paternal allele, which is associated with growth suppression. Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers. -
Synonyms
DIRAS3;DIRAS family, GTP-binding RAS-like 3;ARHI, ras homolog gene family, member I;GTP-binding protein Di-Ras3;NOEY2;DIRA3;DIRA3_HUMAN;DIRAS family GTP binding RAS like 3;Distinct subgroup of the Ras family member 3;GTP binding protein Di Ras3;Rho related GTP binding protein RhoI;Rho-related GTP-binding protein RhoI;RHOI;ras homolog gene family, member I;ARHI
Recombinant Proteins
- Rhesus macaque
- Human
- Mammalian Cell
- Human Cell
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian cells
- HEK293T
- His
- GST
- Non
- mFc
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
DIRAS3 involved in several pathways and played different roles in them. We selected most pathways DIRAS3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DIRAS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DIRAS3 has several biochemical functions, for example, GTP binding,GTPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DIRAS3 itself. We selected most functions DIRAS3 had, and list some proteins which have the same functions with DIRAS3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activity | RALAA,RAB4A,GNAT2,RAP1B,TUBA1A,RAB40A,RND2,RAC1,RAB44,RAB5AB |
| protein binding | GTF3C5,BCL9,FAM92A,SRGN,SUPT5H,FAM123A,SCYL3,NAGK,SGIP1,ACTR1B |
| GTP binding | SRP54A,SEPT11,RAB11BB,EEF1A1L1,TUBG1,IRGC,SRPRB,GIMAP5,RRAGB,SEPT5 |
Interacting Protein
DIRAS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DIRAS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DIRAS3.
STAT3;PPM1D;BAG4;CHEK2;KRAS;TGFB1;PTPN1;WT1;FGFR4;APC;PALB2;BRMS1
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