DIO3
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Official Full Name
deiodinase, iodothyronine, type III -
Overview
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3,5-triiodothyronine (T3) to inactive metabolites, 3,3,5-triiodothyronine (RT3) and 3,3-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3 UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. -
Synonyms
DIO3;deiodinase, iodothyronine, type III;TXDI3;type III iodothyronine deiodinase;Type 3 DI;D3;5DIII;Deiodinase iodothyronine type 3;Deiodinase iodothyronine type III;Dio 3;DIOIII;MGC124117;MGC124118;type-III 5 deiodinase;type-III 5-deiodinase;type 3 iodothyronine selenodeiodinase;iodothyronine deiodinase, placental type;thyroxine deiodinase type III (selenoprotein)
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Yeast
- In Vitro Cell Free System
- His
- His&MBP
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DIO3-3713H | Recombinant Human DIO3 protein, His-tagged | E.coli | Human | His | 192-278 aa | |
| DIO3-385R | Recombinant Rat DIO3 Protein, His/MBP-tagged | E.coli | Rat | His&MBP | Arg11~Arg277 | |
| DIO3-1870R | Recombinant Rat DIO3 Protein | Mammalian Cell | Rat | His |
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| DIO3-2629H | Recombinant Human DIO3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DIO3-3832C | Recombinant Chicken DIO3 | Mammalian Cell | Chicken | His |
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| DIO3-4595M | Recombinant Mouse DIO3 Protein | Mammalian Cell | Mouse | His |
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| Dio3-1342M | Recombinant Mouse Dio3 Protein, His-tagged | E.coli | Mouse | His | Arg11-Arg277 |
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| DIO3-1528R | Recombinant Rat DIO3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| DIO3-1528R-B | Recombinant Rat DIO3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| DIO3-1603R | Recombinant Rat DIO3 Protein (37-278 aa), His-tagged | Yeast | Rat | His | 37-278 aa |
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| DIO3-2379M | Recombinant Mouse DIO3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DIO3-2379M-B | Recombinant Mouse DIO3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| DIO3-2565HF | Recombinant Full Length Human DIO3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 143 amino acids |
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| Dio3-4042R | Recombinant Rat Dio3 protein, His-tagged | E.coli | Rat | His | 63-304aa |
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| Dio3-5658R | Recombinant Rat Dio3 protein, His-tagged | Yeast | Rat | His | 63-304aa (170:U→missing) |
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Involved Pathway
DIO3 involved in several pathways and played different roles in them. We selected most pathways DIO3 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DIO3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone signaling pathway | MAP2K2,RCAN1,NCOA3,HDAC1,PLN,RXRB,STAT1,NOTCH4,BAD,AKT1 |
Protein Function
DIO3 has several biochemical functions, for example, oxidoreductase activity,thyroxine 5-deiodinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DIO3 itself. We selected most functions DIO3 had, and list some proteins which have the same functions with DIO3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidoreductase activity | AOX4,FADS3,KDM5BB,CYP2P6,OSGIN1,CYP2X7,AKR7A5,DEGS2,GMPR2,JMJD5 |
| thyroxine 5-deiodinase activity | DIO1,DIO3A,DIO2,DIO3B |
Interacting Protein
DIO3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DIO3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DIO3.
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