DHX38
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Official Full Name
DEAH (Asp-Glu-Ala-His) box polypeptide 38 -
Overview
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process. -
Synonyms
DHX38;DEAH (Asp-Glu-Ala-His) box polypeptide 38;DDX38, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 38;pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16;hPrp16;KIAA0224;PRP16;PRPF16;DEAH box protein 38;PRP16 homolog of S.cerevisiae;ATP-
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- GST
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DHX38-11987H | Recombinant Human DHX38 protein, GST-tagged | E.coli | Human | GST | 19-280 aa | |
| DHX38-11124Z | Recombinant Zebrafish DHX38 | Mammalian Cell | Zebrafish | His |
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| DHX38-1263R | Recombinant Rhesus monkey DHX38 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| DHX38-2295C | Recombinant Chicken DHX38 | Mammalian Cell | Chicken | His |
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| DHX38-2612H | Recombinant Human DHX38 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DHX38-1088R | Recombinant Rhesus Macaque DHX38 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| DHX38-1088R-B | Recombinant Rhesus Macaque DHX38 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
DHX38 involved in several pathways and played different roles in them. We selected most pathways DHX38 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHX38 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | EIF4A3,CCDC12,SNRPC,U2AF1,SYF2,NHP2L1,SNRPA,SRSF2A,PQBP1,SRSF3 |
Protein Function
DHX38 has several biochemical functions, for example, ATP binding,ATP-dependent RNA helicase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DHX38 itself. We selected most functions DHX38 had, and list some proteins which have the same functions with DHX38. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP-dependent RNA helicase activity | DDX20,DDX49,DDX3X,DHX33,EIF4A2,DDX10,DHX37,DDX43,DDX41,ACTG2 |
| ATP binding | ADCY6,ACTR1A,SPHK1,MTPAP,AK4,TTBK2,ADK,KIFC1,GUK1,NUAK1 |
| poly(A) RNA binding | PPIE,NOP56,MTHFSD,MRPS31,RPS21,COX4I2,SECISBP2,ZC3HAV1,FAM98C,WDR3 |
| protein binding | DDX19A,TCHP,CORO1C,WHSC1,NR4A1,THOC1,GBP2,TNFAIP8L1,SPRED1,RNF14 |
Interacting Protein
DHX38 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHX38 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHX38.
DHX16;RBM10;GPKOW;TERF2IP;NUDCD1;CSNK2A1;RNPS1;USP39;Prpf8;MFAP1;U2AF1;murF;ssrna_ug;PPP4C
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References
- Jung, JY; Lee, SR; et al. Identification of Novel Binding Partners for Caspase-6 Using a Proteomic Approach. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY 24:714-718(2014).
- Li, XP; Kim, SW; et al. Analyses of porcine public SNPs in coding-gene regions by re-sequencing and phenotypic association studies. MOLECULAR BIOLOGY REPORTS 38:3805-3820(2011).
- Ancelin, K; Lange, UC; et al. Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. NATURE CELL BIOLOGY 8:623-630(2006).
- Ajmal, M; Khan, MI; et al. A missense mutation in the splicing factor gene DHX38 is associated with early-onset retinitis pigmentosa with macular coloboma. JOURNAL OF MEDICAL GENETICS 51:444-448(2014).
