DHPS
-
Official Full Name
deoxyhypusine synthase -
Overview
This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
DHPS;deoxyhypusine synthase;MIG13;migration inducing gene 13;DHS;DHYS_HUMAN;DS;migration-inducing gene 13
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DHPS involved in several pathways and played different roles in them. We selected most pathways DHPS participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation,Hypusine synthesis from eIF5A-lysine,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHPS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hypusine synthesis from eIF5A-lysine | EIF5A2,EIF5A,DOHH |
| Metabolism of proteins | GRPEL1,CPA3,IGFBP2,RHBDL1,STT3A,MPDU1,TIMM44,GALNTL5,ADAMTS10,IGFBP6 |
| Gamma carboxylation, hypusine formation and arylsulfatase activation | DPH2,SUMF2,FURINA,PROCA,ARSF,PROZ,FURINB,GAS6,OTOP2,DNAJC24 |
| Post-translational protein modification | SEC23IP,ARSH,STT3A,ADAMTSL4,NEU4,MGAT4A,TRAPPC6BL,ATPBD4,MUC12,NSMCE4A |
| hypusine biosynthesis | DOHH |
Protein Function
DHPS has several biochemical functions, for example, deoxyhypusine synthase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DHPS itself. We selected most functions DHPS had, and list some proteins which have the same functions with DHPS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NDE1,SLBP,ZNF599,ZNF263,CST1,MFN2,BAZ1A,SWSAP1,FRAS1,CLEC16A |
Interacting Protein
DHPS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHPS here. Most of them are supplied by our site. Hope this information will be useful for your research of DHPS.
MAPK3;RPL9P7;EIF5A2;NUDT18;NIF3L1;RAB27B
Resources
Related Services
Related Products
References
- Liang, X; Wang, ZH; et al. A proof-of-concept receptor-based assay for sulfonamides. ANALYTICAL BIOCHEMISTRY 438:110-116(2013).
- Kyan, H; Taira, M; et al. Isolation and Characterization of Toxoplasma gondii Genotypes from Goats at an Abattoir in Okinawa. JAPANESE JOURNAL OF INFECTIOUS DISEASES 65:167-170(2012).
