DHDH
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Official Full Name
dihydrodiol dehydrogenase (dimeric) -
Overview
This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. -
Synonyms
DHDH;dihydrodiol dehydrogenase (dimeric);trans-1,2-dihydrobenzene-1,2-diol dehydrogenase;HUM2DD;D-xylose 1-dehydrogenase;3-deoxyglucosone reductase;D-xylose-NADP dehydrogenase;2DD
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DHDH involved in several pathways and played different roles in them. We selected most pathways DHDH participated on our site, such as Pentose and glucuronate interconversions,Metabolism of xenobiotics by cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pentose and glucuronate interconversions | UGT1A3,UGT1A7,AKR1A1B,GUSB,UGP2B,UGT2A3,UGT2A1,UGT1A9,RPE,AKR1A1A |
| Metabolism of xenobiotics by cytochrome P | GSTA3,GSTO1,CYP2F2,AKR7A2,GSTM1,CBR1,UGT1A7C,MGST1,GSTM4,UGT2B15 |
Protein Function
DHDH has several biochemical functions, for example, D-xylose 1-dehydrogenase (NADP+) activity,NAD(P)+ transhydrogenase activity,electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DHDH itself. We selected most functions DHDH had, and list some proteins which have the same functions with DHDH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity | AKR1C3,AKR1C2,AKR1C21 |
| electron carrier activity | TXNRD1,GLRX5,QDPR,AIFM1,GLDC,AOX3,ETFDH,IDH3B,CIAPIN1,SDHC |
| NAD(P)+ transhydrogenase activity | NNT |
| D-xylose 1-dehydrogenase (NADP+) activity | DHDHL |
Interacting Protein
DHDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHDH here. Most of them are supplied by our site. Hope this information will be useful for your research of DHDH.
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References
- Aro-Karkkainen, N; Toivari, M; et al. L-Arabinose/D-galactose 1-dehydrogenase of Rhizobium leguminosarum bv. trifolii characterised and applied for bioconversion of L-arabinose to L-arabonate with Saccharomyces cerevisiae. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 98:9653-9665(2014).
- Meneely, KM; Lamb, AL; et al. Two Structures of a Thiazolinyl Imine Reductase from Yersinia enterocolitica Provide Insight into Catalysis and Binding to the Nonribosomal Peptide Synthetase Module of HMWP1. BIOCHEMISTRY 51:9002-9013(2012).
