DGKG
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Official Full Name
diacylglycerol kinase, gamma 90kDa -
Overview
This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
DGKG;diacylglycerol kinase, gamma 90kDa;DAGK3, diacylglycerol kinase, gamma (90kD);diacylglycerol kinase gamma;DAG kinase gamma;diglyceride kinase gamma;diacylglyerol kinase gamma;DAGK3;DGK-GAMMA;MGC104993;MGC133330
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Insect Cell
- In Vitro Cell Free System
- HEK293T
- His&T7
- His
- GST
- Non
- His&Fc&Avi
- His&SUMO
- Myc&DDK
Involved Pathway
DGKG involved in several pathways and played different roles in them. We selected most pathways DGKG participated on our site, such as Choline metabolism in cancer,Effects of PIP2 hydrolysis,G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGKG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hemostasis | CEACAM8,BA2,KIF4,APOA1B,HBD,HBE1,MFN2,SLC16A8,AMICA1,CD9B |
| G alpha (q) signalling events | EDNRB,NMU,ABHD6B,FPR-RS3,TRH,FPR-RS4,LPAR2B,TAC1,ANXA1B,CCK |
| GPCR downstream signaling | PIK3R6,OXGR1A.2,NTS,TRPC7,SCT,PTH2,ECT2,APLN,CALCRL,DCLRE1B |
| Glycerophospholipid metabolism | GPAM,PLA2G4AA,LYPLA2,PLA2G4C,CHPT1,ETNK1,LPCAT2,PLA2G12B,PCYT2,GPCPD1 |
| Glycerolipid metabolism | AGK,MBOAT2B,AGPAT1,AKR1B1,PPAP2C,LIPC,ALDH7A1,ALDH2.2,DGKZ,AGPAT5 |
| Gastrin-CREB signalling pathway via PKC and MAPK | GPR132,MLN,ANXA1C,OPN4.1,LPAR1,TRIO,GCGB,NMBA,ANXA1B,ARHGEF25 |
| Choline metabolism in cancer | PIP5K1C,SP1,AKT1,PDGFB,PLA2G4C,MAP2K1,PIP5K1A,RAC2,PIK3CD,WASL |
| Effects of PIP2 hydrolysis | TRPC7,TAE1,PRKCHB,RASGRP2,DGKQ,TRPC3,ABHD12,TRPC6A,ABHD6B,DGKA |
Protein Function
DGKG has several biochemical functions, for example, ATP binding,calcium ion binding,diacylglycerol kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DGKG itself. We selected most functions DGKG had, and list some proteins which have the same functions with DGKG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| diacylglycerol kinase activity | DGKE,DGKQ,DGKB,DGKZ,AGK,TAE1,DGKAA,DGKD,DGKA |
| ATP binding | DDX3X,ITPKC,ATP5A1,PDK4,ATM,DDX55,IPPK,BUB1B,KIF2B,ABCB1A |
| calcium ion binding | RCN1,PLCD4,LRP2,ANXA1B,Npnt,DHH,SCUBE3,F9,ACTN2B,NINL |
Interacting Protein
DGKG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGKG here. Most of them are supplied by our site. Hope this information will be useful for your research of DGKG.
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References
- Lisowski, P; Wieczorek, M; et al. Effects of Chronic Stress on Prefrontal Cortex Transcriptome in Mice Displaying Different Genetic Backgrounds. JOURNAL OF MOLECULAR NEUROSCIENCE 50:33-57(2013).
- Vahtola, E; Storvik, M; et al. Effects of Levosimendan on Cardiac Gene Expression Profile and Post-Infarct Cardiac Remodelling in Diabetic Goto-Kakizaki Rats. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 109:387-397(2011).
