DGCR8
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Official Full Name
DGCR8 microprocessor complex subunit -
Overview
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] -
Synonyms
DGCR8;DGCR8 microprocessor complex subunit;Gy1;pasha;DGCRK6;C22orf12;microprocessor complex subunit DGCR8;DiGeorge syndrome critical region 8;DiGeorge syndrome critical region gene 8
Recombinant Proteins
- Rhesus macaque
- Human
- Mouse
- Zebrafish
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
DGCR8 involved in several pathways and played different roles in them. We selected most pathways DGCR8 participated on our site, such as Direct p53 effectors,Gene Expression,Gene Silencing by RNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGCR8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNA (miRNA) biogenesis | BARHL1,TARBP2 |
| Gene Silencing by RNA | AGO3B,TSN,DDX4,MYBL1,ASZ1,DPY19L2,PIWIL4,IPO8,TNRC6B,TARBP2 |
| Direct p53 effectors | NDRG1,EPHA2,GDF15,CTSD,DUSP1,PPM1J,TADA2B,ARID3A,SMARCA4,CSE1L |
| Gene Expression | EIF4B,KRBA1,SUZ12,ZNF333,KRBOX4,ZNF37A,ZNF100,ZNF167,YAP1,FARS2 |
Protein Function
DGCR8 has several biochemical functions, for example, double-stranded RNA binding,heme binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DGCR8 itself. We selected most functions DGCR8 had, and list some proteins which have the same functions with DGCR8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heme binding | CYP4Z1,CYP8B3,CYP2AA2,HBAA,PTGS2,CYP7B1,PTGS2A,HBB-Y,CYP2D10,CYP2F2 |
| primary miRNA binding | SRF |
| protein homodimerization activity | TIRAP,HIF1AN,PSPH,PSMD7,NR6A1B,MVD,CD2,CRYAB,OLFM4,KCNK3 |
| metal ion binding | TGM1,NEK3,VSNL1A,ZNF669,TRIM35-29,GLI1,ZFP768,DGKAA,ZNF200,SMAP1 |
| protein binding | TSPO,LGALS3,CCNA2,IRAK1BP1,HDLBP,FGFR3,PEX10,PDGFB,GLA,HIST4H4 |
| double-stranded RNA binding | LSM14A,EIF2C3,TLR3,DROSHA,ELAVL1,TLR8,OAS1A,MSN,LRRFIP1,STAU2 |
Interacting Protein
DGCR8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGCR8 here. Most of them are supplied by our site. Hope this information will be useful for your research of DGCR8.
DROSHA;SRPK1;MEOX2;DDX17;EEF1D;HNRNPUL1;KIF15
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