DFFB
-
Official Full Name
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -
Overview
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013] -
Synonyms
DFFB;DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase);CAD;CPAN;DFF2;DFF40;DFF-40;DNA fragmentation factor subunit beta;caspase-activated DNase;caspase-activated nuclease;caspase-activated deoxyribonuclease;DNA fragmentation factor 40 kDa subunit
Recombinant Proteins
- Human
- Rat
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E. coli
- His&T7
- His
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DFFB-1446H | Recombinant Human DFFB protein, His & T7-tagged | E.coli | Human | His&T7 | Arg87~Lys323 |
|
| DFFB-1850R | Recombinant Rat DFFB Protein | Mammalian Cell | Rat | His |
|
|
| DFFB-2557H | Recombinant Human DFFB Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| DFFB-5858C | Recombinant Chicken DFFB | Mammalian Cell | Chicken | His |
|
|
| DFFB-9754Z | Recombinant Zebrafish DFFB | Mammalian Cell | Zebrafish | His |
|
|
| DFFB-1508R | Recombinant Rat DFFB Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| DFFB-1508R-B | Recombinant Rat DFFB Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| DFFB-1957H | Recombinant Human DFFB Protein(1-338aa), His-tagged | E.coli | Human | His | 1-338aa |
|
| DFFB-2481HF | Recombinant Full Length Human DFFB Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 338 amino acids |
|
| DFFB-41H | Recombinant Human DFFB Protein, Q201-Q338, C-His tagged | E. coli | Human | His | Q201-Q338 |
|
Involved Pathway
DFFB involved in several pathways and played different roles in them. We selected most pathways DFFB participated on our site, such as Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DFFB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | IL1R1,CASP3A,DIABLOB,NFKBIAB,PPP3CCB,MAP3K14,CYCS,LMNB1,PPP3R1,MYC |
Protein Function
DFFB has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DFFB itself. We selected most functions DFFB had, and list some proteins which have the same functions with DFFB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
DFFB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DFFB here. Most of them are supplied by our site. Hope this information will be useful for your research of DFFB.
Resources
Related Services
Related Products
References
