DFFA
-
Official Full Name
DNA fragmentation factor, 45kDa, alpha polypeptide -
Overview
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
DFFA;DNA fragmentation factor, 45kDa, alpha polypeptide;DFF1;ICAD;DFF-45;DNA fragmentation factor subunit alpha;DFF45;inhibitor of CAD;DNA fragmentation factor 45 kDa subunit
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Zebrafish
- Human
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- His&T7
- Myc&DDK
Involved Pathway
DFFA involved in several pathways and played different roles in them. We selected most pathways DFFA participated on our site, such as Activation of DNA fragmentation factor,Apoptosis,Apoptosis Modulation and Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DFFA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | IL1B2,GZMC,PRKAR2A,Casp3,BNIP3L,HMGB2A,IKBKB,NGF,PPP3CCA,DSG2 |
| Caspase cascade in apoptosis | LMNB1,DIABLO,TFAP2A,NUMA1,CASP2,CFL2,GAS2,CRADD,CASP4,PARP1 |
| HIV-1 Nef: Negative effector of Fas and TNF-alpha | CASP2,DAXX,CRADD |
| Apoptosis induced DNA fragmentation | HMGB2A,HMGB2,H1F0,HIST1H1C,HIST1H1E,HIST1H1D,HIST1H1A,HIST1H1B |
| Apoptosis Modulation and Signaling | SEPT4,CASP2,BAG3,HRK,BOK,PTPN13,BLK,CRADD,BCL2L10,PTRH2 |
| Activation of DNA fragmentation factor | HIST1H1D,HIST1H1C,HIST1H1A,HMGB2,HIST1H1E,HMGB2A,H1F0,HIST1H1B |
| Apoptotic execution phase | DSG1,CTNNB2,PANK1A,HIST1H1E,HIST1H1C,DBNLA,DBNL,HIST1H1A,SATB1,HMGB2 |
| FAS pathway and Stress induction of HSP regulation | FAF1,LMNB2,DAXX |
Protein Function
DFFA has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DFFA itself. We selected most functions DFFA had, and list some proteins which have the same functions with DFFA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MYH8,INO80,F5,FRAS1,ZNF187,HGS,RNPS1,FGA,TEAD3,C1orf109 |
Interacting Protein
DFFA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DFFA here. Most of them are supplied by our site. Hope this information will be useful for your research of DFFA.
DFFB;YWHAG;YWHAZ;HSPB1;Dffb;7460242
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