DENND1B
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Official Full Name
DENN/MADD domain containing 1B -
Overview
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members;of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early;endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024).;Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 (PubMed;20154091)). -
Synonyms
DENND1B;DENN/MADD domain containing 1B;C1orf218, chromosome 1 open reading frame 218 , FAM31B, family with sequence similarity 31, member B;DENN domain-containing protein 1B;FLJ20054;MGC27044;C1ORF18;C1orf218;Chromosome 1 open reading frame 218;DEN1B_HUMAN;DENN domain containing protein 1B;DENN MADD domain containing 1B;DKFZp547O0715;FAM31B;Family with sequence similarity 31 member B;FLJ21179;FLJ33888;MGC103810;Protein FAM31B;connecdenn 2;family with sequence similarity 31, member B;RP11-53I24.2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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| DENND1B-015H | Recombinant Human CCDC112 protein, HIS-tagged | E.coli | Human | HIS |
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| DENND1B-2533H | Recombinant Human DENND1B Protein, GST-tagged | Wheat Germ | Human | GST |
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| DENND1B-465HCL | Recombinant Human DENND1B cell lysate | Human | Non |
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| DENND1B-2460HF | Recombinant Full Length Human DENND1B Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 396 amino acids |
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Involved Pathway
DENND1B involved in several pathways and played different roles in them. We selected most pathways DENND1B participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DENND1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
DENND1B has several biochemical functions, for example, Rab guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DENND1B itself. We selected most functions DENND1B had, and list some proteins which have the same functions with DENND1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rab guanyl-nucleotide exchange factor activity | DENND4C,ST5,ALS2,DENND4B,PRSS56,RGP1,RAB3IP,DENND5A,DENND2D,DENND3 |
Interacting Protein
DENND1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DENND1B here. Most of them are supplied by our site. Hope this information will be useful for your research of DENND1B.
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References
- Chawes, BLK; Bischoff, AL; et al. DENND1B Gene Variants Associate With Elevated Exhaled Nitric Oxide in Healthy High-Risk Neonates. PEDIATRIC PULMONOLOGY 50:109-117(2015).
- Smith, NLD; Hankinson, J; et al. Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in Chronic cavitary pulmonary aspergillosis, and novel associations of VEGFA, DENND1B and PLAT. CLINICAL MICROBIOLOGY AND INFECTION 20:O960-O968(2014).
