DDX23
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Official Full Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 -
Overview
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. -
Synonyms
DDX23;DEAD (Asp-Glu-Ala-Asp) box polypeptide 23;PRP28 homolog, yeast;probable ATP-dependent RNA helicase DDX23;prp28;PRPF28;U5 100K;PRP28p homolog;DEAD box protein 23;U5 snRNP 100 kD protein;100 kDa U5 snRNP-specific protein;U5-100K;U5-100KD
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DDX23 involved in several pathways and played different roles in them. We selected most pathways DDX23 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX23 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | PRPF19,CTNNBL1,PRPF4,TTC6,RP9,ZMAT2,CWC15,DHX8,TCERG1,SNRPF |
Protein Function
DDX23 has several biochemical functions, for example, ATP binding,ATP-dependent RNA helicase activity,NOT ATP-dependent helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX23 itself. We selected most functions DDX23 had, and list some proteins which have the same functions with DDX23. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CCT4,FLJ11011L,MAP3K6,NLRP4C,MYH4,NLK2,IFIH1,ZAP70,LIG1,NEK10 |
| poly(A) RNA binding | PDAP1,RPP25L,EIF4A3,RRP1,TBCA,ZFP36L1,VCP,SND1,GRN,ZNF207 |
| ATP-dependent RNA helicase activity | SUPV3L1,DHX57,DDX19A,DDX19,DDX31,DDX43,DHX32,DDX39,TMEM38A,EIF4A1A |
| protein binding | SCMH1,NR2F2,CDC20,TRIAP1,ASB9,RNMT,IARS,SUFU,SLIRP,SPTA1 |
Interacting Protein
DDX23 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX23 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX23.
PRPF4;SNW1;TERF1;WBP4;CD2BP2;RNPS1;SF3A2;USP39;SNRNP40;Prpf8;BNLF1;q7cia4_yerpe;TERF2IP;ssrna_ag;Junb;TOP1
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